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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Markworth, James F. Cameron-Smith, David |
| Description | Country affiliation: Australia Author Affiliation: Markworth JF ( School of Exercise and Nutrition Sciences, Deakin Univ., 221 Burwood Highway, Burwood, Victoria 3125, Australia.) |
| Abstract | Cyclooxygenase (COX) enzymes mediate the synthesis of proinflammatory prostaglandin (PG) species from cellular arachidonic acid. COX/PGs have been implicated in skeletal muscle growth/regeneration; however, the mechanisms by which PGs influence skeletal muscle adaptation are poorly understood. The present study aimed to investigate PGF(2 ) signaling and its role in skeletal myotube hypertrophy. PGF(2 ) or the FP receptor agonist fluprostenol increased C2C12 myotube diameter. This effect was abolished by the FP receptor antagonist AL8810 and mammalian target of rapamycin (mTOR) inhibition. PGF(2 ) stimulated time- and dose-dependent increases in the phosphorylation of extracellular receptor kinase (ERK)1/2 (Thr202/Tyr204), p70S6 kinase (p70S6K) (Thr389 and Thr421/Ser424), and eukaryotic initiation factor 4G (eIF4G) (Ser1108) without influencing Akt (Ser473). Pretreatment with the phosphoinositide 3-kinase (PI3K) inhibitor LY294002 and the ERK inhibitor PD98059 blocked F prostanoid receptor signaling responses, whereas rapamycin blocked heightened p70S6K/eIF4G phosphorylation without influencing ERK1/2 phosphorylation. These data suggest that activation of the F prostanoid receptor is coupled to C2C12 myotube growth and intracellular signaling via a PI3K/ERK/mTOR-dependent pathway. |
| File Format | HTM / HTML |
| ISSN | 03636143 |
| e-ISSN | 15221563 |
| Journal | American Journal of Physiology - Cell Physiology |
| Issue Number | 3 |
| Volume Number | 300 |
| Language | English |
| Publisher | American Physiological Society |
| Publisher Date | 2011-03-01 |
| Publisher Place | United States |
| Access Restriction | Open |
| Subject Keyword | Discipline Cell Biology Extracellular Signal-regulated Map Kinases Physiology Muscle Fibers, Skeletal Metabolism Muscle, Skeletal Pathology Phosphatidylinositol 3-kinases Signal Transduction Tor Serine-threonine Kinases Animals Cell Differentiation Cell Line Cell Movement Hypertrophy Map Kinase Signaling System Mice Enzymology Myoblasts |
| Content Type | Text |
| Resource Type | Article |
| Subject | Cell Biology Physiology |
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