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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Kilpinen, Susanne Rantala, Merja Spillmann, Thomas Björkroth, Johanna Westermarck, Elias |
| Description | Author Affiliation: Kilpinen S ( Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, FI-00014 Helsinki, Finland. Electronic address: susanne.kilpinen@helsinki.fi.); Rantala M ( Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, FI-00014 Helsinki, Finland.); Spillmann T ( Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, FI-00014 Helsinki, Finland.); Björkroth J ( Department of Food Hygiene and Environmental Health, Faculty of Veterinary Medicine,University of Helsinki, P.O. Box 66, FI-00014 Helsinki, Finland.); Westermarck E ( Department of Equine and Small Animal Medicine, Faculty of Veterinary Medicine, University of Helsinki, P.O. Box 57, FI-00014 Helsinki, Finland.) |
| Abstract | The term tylosin-responsive diarrhoea (TRD) is used for canine recurrent diarrhoea cases for which no underlying cause can be found after extensive diagnostic investigations, but which show a response to the antibiotic tylosin in a few days. The objective of this prospective, one-arm longitudinal trial was to assess the effects of oral tylosin administration on the faecal levels of potentially probiotic bacteria, such as Enterococcus spp. and lactic acid bacteria (LAB), in dogs with TRD. This trial included 14 client-owned suspected TRD dogs that were on tylosin treatment and had firm faeces. Treatment was then terminated and dogs were followed up for up to 2 months to determine the recurrence of diarrhoea. Once diarrhoea started, dogs received tylosin (orally, 25 mg/kg, once daily for 7 days). At the end of the treatment period, stools were firm again in 11 dogs (TRD dogs); three dogs continued having diarrhoea and were excluded from the study. Faecal samples were collected at all three time-points for culture of LAB and enterococci. In TRD dogs, the colony counts of Enterococcus spp. (P = 0.003), LAB (P = 0.037), tylosin-resistant Enterococcus spp. (P <0.001) and LAB (P <0.001) were significantly higher when the dogs were on tylosin treatment and had normal faecal consistency compared to when they had diarrhoea following discontinuation of tylosin. In conclusion, cessation of diarrhoea in TRD dogs with tylosin treatment could be mediated by selection of a specific lactic acid population, the Enterococcus spp., due to their potential probiotic properties. |
| File Format | HTM / HTML |
| ISSN | 10900233 |
| Issue Number | 3 |
| Volume Number | 205 |
| e-ISSN | 15322971 |
| Journal | The Veterinary Journal |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-09-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Enterococcus Recurrence Research Support, Non-u.s. Gov't Microbiology Administration, Oral Lactic Acid Drug Therapy Discipline Veterinary Medicine Diarrhea Drug Resistance, Bacterial Double-blind Method Randomized Controlled Trial Drug Effects Anti-bacterial Agents Therapeutic Use Journal Article Probiotics Animals Dogs Tylosin Feces Veterinary Chronic Disease Lactobacillales |
| Content Type | Text |
| Resource Type | Article |
| Subject | Veterinary Animal Science and Zoology |
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