NDLI: Clinical utility of the cobalt-albumin binding assay in the diagnosis of intestinal ischemia.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Polk, Jonathan D. Rael, Leonard T. Craun, Michael L. Mains, Charles W. Davis-Merritt, Deborah Bar-Or, David
Description	Country affiliation: United States Author Affiliation: Polk JD ( Saint Joseph Hospital, Denver, Colorado, USA.)
Abstract	Currently, the rapid diagnosis of mesenteric ischemia is problematic because of the nonspecificity of most laboratory assays and the unreliability of physical examinations. The evaluation of the cobalt-albumin binding assay (CABA) as a diagnostic marker for short-term risk stratification of emergency department patients presenting with symptoms of intestinal ischemia is reported. This preliminary study includes patients scheduled for exploratory laparotomy with symptoms of ischemic bowel and/or bowel obstruction. Approximately 10 mL of blood was drawn from each patient 1 hour preoperatively into a serum separator gel tube. After 30 minutes of clotting time, serum was collected and frozen at -80 degrees C. The CABA test was performed on the samples by an investigator blinded to the patient's condition, and values were compared with the clinical and pathologic diagnosis of ischemic bowel postoperatively. CABA test values are reported as absorbance units (ABSU) at 470 nm. Of the 26 patients enrolled in the study, 12 were clinically diagnosed with intestinal ischemia. These patients had significantly higher CABA test values (0.52 ABSU +/- 0.04 SEM) than patients without intestinal ischemia (0.31 ABSU +/- 0.02 SEM, p = 0.00023). Only two false-positives and no false-negatives were recorded. This resulted in a sensitivity of 100% and a specificity of 85.7% for the CABA test for these particular samples. The CABA test could be a useful tool for clinicians in the risk stratification of intestinal ischemia.
File Format	HTM / HTML
ISSN	00225282
Issue Number	1
Volume Number	64
e-ISSN	15298809
Journal	The Journal of Trauma: Injury, Infection, and Critical Care
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2008-01-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Prospective Studies Blood Supply Biological Markers Humans Middle Aged Male Abdominal Pain Roc Curve Cobalt Blood Journal Article Ischemia Etiology Female Diagnosis Spectrum Analysis Intestinal Obstruction Intestines Sensitivity And Specificity Clinical Trial Metabolism Discipline Traumatology Serum Albumin Pilot Projects Aged
Content Type	Text
Resource Type	Article
Subject	Surgery Critical Care and Intensive Care Medicine

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