NDLI: Mobilization of bone marrow cells to the site of injury is necessary for wound healing.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Shah, Salil Ulm, Jason Sifri, Ziad C. Mohr, Alicia M. Livingston, David H.
Description	Country affiliation: United States Author Affiliation: Shah S ( Division of Trauma, Department of Surgery, UMDNJ-New Jersey Medical School, Newark, New Jersey, USA.)
Abstract	INTRODUCTION: Lung contusion (LC) and hemorrhagic shock (HS) result in early organ failure (lung and bone marrow [BM]), possibly through sequestration of mobilized BM hematopoietic progenitor cells (HPC) into the lung. Postinjury mesenteric lymph has been shown to cause early organ failure. Thus, we hypothesized that diversion of mesenteric lymph would improve early organ dysfunction through decreased mobilization of BM HPC to the lung. METHODS: Rats were subjected to unilateral LC +/- lymph duct ligation (LDL). Additional groups underwent HS (mean arterial pressure of 35 mm Hg for 90 minutes) with and without LC +/- LDL. Controls were only cannulated. At 3 hours, both lungs and BM were harvested for growth of HPC (BFU-E, CFU-E, and CFU-GEMM). Additional rats were killed on day 14 and the lungs examined by histology. RESULTS: LC alone decreased BM HPC in all cell types and increased their number in the injured lung (all *p < 0.05 vs. control). Shock exacerbated these results and resulted in a further increase in BM cells in the injured lung and a decrease in BM HPC growth. LDL reversed the response to LC alone. In rats subjected to LC and HS, LDL restored BM HPC growth to levels observed after LC alone and decreased HPC recovered in the contused lung 50% compared with that in shocked rats without LDL. At day 14, all rats subjected to LC demonstrated healing of their injury. In contrast, all LC + LDL rats had evidence of pneumonia, thickened alveoli, and increased numbers of inflammatory cells. CONCLUSIONS: Diversion of the postinjury mesenteric lymph decreased early BM suppression after LC or LC with HS. However, this improved BM function occurred at the expense of impaired lung healing and an increased susceptibility to pulmonary infection. As mobilized BM cells differentiate into pneumocytes, these data indicate that mobilization of BM cells to the site of injury is an adaptive and necessary response for successful wound healing and tissue repair.
File Format	HTM / HTML
ISSN	00225282
Issue Number	2
Volume Number	67
e-ISSN	15298809
Journal	The Journal of Trauma: Injury, Infection, and Critical Care
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2009-08-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Complications Cytology Rats Male Wound Healing Discipline Traumatology Journal Article Physiopathology Wounds, Nonpenetrating Shock, Hemorrhagic Bone Marrow Cells Animals Immunology Lung Injury Physiology Hematopoietic Stem Cells Cell Movement Lymph
Content Type	Text
Resource Type	Article
Subject	Surgery Critical Care and Intensive Care Medicine

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