NDLI: Liver T1ρ MRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence.

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Liver T1ρ MRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence.

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Liver T1ρ MRI measurement in healthy human subjects at 3 T: a preliminary study with a two-dimensional fast-field echo sequence.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Deng, M. Zhao, F. Yuan, J. Ahuja, A. T. Wang, Y-X J.
Description	Country affiliation: China Author Affiliation: Deng M ( Department of Imaging and Interventional Radiology, Prince of Wales Hospital, The Chinese University of Hong Kong, Shatin, Hong Kong SAR, China.)
Abstract	OBJECTIVES: The aim of this study was to explore the technical feasibility of T(1)ρ MRI for the liver, and to determine the normal range of liver T(1)ρ in healthy subjects at clinical 3 T. METHODS: There were 15 healthy volunteers. Three representative axial slices were selected to cut through the upper, middle and lower liver. A rotary echo spin-lock pulse was implemented in a two-dimensional fast-field echo sequence. Spin-lock frequency was 500 Hz, and the spin-lock times of 1, 10, 20, 30, 40 and 50 ms were used for T(1)ρ mapping. The images were acquired slice by slice during breath-holding. Regions of interest (ROIs; n=5) were manually placed on each slice of the liver parenchyma region, excluding artefacts and vessels. The mean value of these ROIs (n=15) was regarded as the liver T(1)ρ value for the subject. Six subjects were scanned once at fasting status; six subjects were scanned once 2 h post meal; three subjects were scanned twice at fasting status; and seven subjects were scanned twice 2 h post meal. RESULTS: When two readers measured the same 10 data sets, the interreader reproducibility (ICC: intraclass correlation coefficient) was 0.955. With the 10 subjects scanned twice, the ICC for scan-rescan reproducibility was 0.764. There was no significant difference for the liver T(1)ρ value at the fasting status (43.08±1.41 ms) and post-meal status (42.97±2.38 ms, p=0.867). Pooling together all the 32 scans in this study, the normal liver T(1)ρ value ranged from 38.6 to 48.3 ms (mean 43.0 ms, median 42.6 ms). CONCLUSION: It is feasible to obtain consistent liver T(1)ρ measurement for human subjects at 3 T.
File Format	HTM / HTML
ISSN	00071277
DOI	10.1259/bjr/98745548
Journal	The British Journal of Radiology
Issue Number	1017
Volume Number	85
Language	English
Publisher	BIR Publications
Publisher Date	2012-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Research Support, Non-u.s. Gov't Sensitivity And Specificity Image Enhancement Liver Anatomy & Histology Reference Values Reproducibility Of Results Pilot Projects Echo-planar Imaging Discipline Radiology
Content Type	Text
Resource Type	Article

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