NDLI: Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.

Please wait, while we are loading the content...

Impact of the tumor necrosis factor receptor-associated protein 1 (Trap1) on renal DNaseI shutdown and on progression of murine and human lupus nephritis.

Resveratrol reverses remodeling in hearts with large, old myocardial infarctions through enhanced autophagy-activating AMP kinase pathway.

The involvement of collagen triple helix repeat containing 1 in muscular dystrophies.

Loss of ß-catenin induces multifocal periosteal chondroma-like masses in mice.

Regulation and role of connective tissue growth factor in AngII-induced myocardial fibrosis.

Intestinal epithelial cell-derived µ-opioid signaling protects against ischemia reperfusion injury through PI3K signaling.

Derlin-1 is overexpressed in non-small cell lung cancer and promotes cancer cell invasion via EGFR-ERK-mediated up-regulation of MMP-2 and MMP-9.

Inhibition of AMP-activated protein kinase accentuates lipopolysaccharide-induced lung endothelial barrier dysfunction and lung injury in vivo.

Kupffer cells protect liver sinusoidal endothelial cells from Fas-dependent apoptosis in sepsis by down-regulating gp130.

Axonopathy in an -synuclein transgenic model of Lewy body disease is associated with extensive accumulation of C-terminal-truncated -synuclein.

Interferon Î³-dependent migration of microglial cells in the retina after systemic cytomegalovirus infection.

Absence of Nogo-B (reticulon 4B) facilitates hepatic stellate cell apoptosis and diminishes hepatic fibrosis in mice.

Conditionally ablated Pten in prostate basal cells promotes basal-to-luminal differentiation and causes invasive prostate cancer in mice.

Interaction of MCM7 and RACK1 for activation of MCM7 and cell growth.

Involvement of IL-1 and oncostatin M in acanthosis associated with hypertensive leg ulcer.

Lipid droplet accumulation is associated with an increase in hyperglycemia-induced renal damage: prevention by liver X receptors.

Alterations in glucose homeostasis in a murine model of Chagas disease.

Transgenic Mice Overexpressing Neuregulin-1 Model Neurofibroma-Malignant Peripheral Nerve Sheath Tumor Progression and Implicate Specific Chromosomal Copy Number Variations in Tumorigenesis

PIN1 inhibits apoptosis in hepatocellular carcinoma through modulation of the antiapoptotic function of survivin.

Protease activity enhances production of thymic stromal lymphopoietin and basophil accumulation in flaky tail mice.

Poliovirus receptor (CD155) regulates a step in transendothelial migration between PECAM and CD99.

Bullous Pemphigoid IgG Induces BP180 Internalization via a Macropinocytic Pathway

The DNA methylomes of serous borderline tumors reveal subgroups with malignant- or benign-like profiles.

Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.

Single nucleotide polymorphism array analysis of uveal melanomas reveals that amplification of CNKSR3 is correlated with improved patient survival.

It's a cell-eat-cell world: autophagy and phagocytosis.

Creationism and evolutionism in prions.

Activation of cannabinoid CB2 receptor-mediated AMPK/CREB pathway reduces cerebral ischemic injury.

Monocyte/macrophage MMP-14 modulates cell infiltration and T-cell attraction in contact dermatitis but not in murine wound healing.

Convergent replication of mouse synthetic prion strains.

Risk factors for pancreatic ductal adenocarcinoma specifically stimulate pancreatic duct glands in mice.

Death-associated protein kinase controls STAT3 activity in intestinal epithelial cells.

Year: 2013 Volume: 182 Issue: 2

Year: 2013 Volume: 182 Issue: 1

Year: 2012 Volume: 181

Year: 2012 Volume: 180

Year: 2011 Volume: 179

Year: 2011 Volume: 178

Year: 2010 Volume: 177

Year: 2010 Volume: 176

Year: 2009 Volume: 175

Year: 2009 Volume: 174

Year: 2008 Volume: 173

Year: 2008 Volume: 172

Year: 2004 Volume: 164

Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kissoon-Singh, Vanessa Moreau, France Trusevych, Elizabeth Chadee, Kris
Description	Country affiliation: Canada Author Affiliation: Kissoon-Singh V ( Department of Microbiology, Immunology and Infectious Diseases, Snyder Institute for Chronic Diseases, Gastrointestinal Research Group, University of Calgary Health Sciences Centre, Calgary, Alberta, Canada.)
Abstract	Human mucin-2 (MUC-2) is the first line of innate host defense in preventing pathogen-induced epithelial injury. Entamoeba histolytica (Eh) colonizes the mucus layer by binding of the parasite's surface galactose lectin to galactose and N-acetyl-d-galactosamine residues on colonic MUC-2, preventing parasite contact-dependent cytolysis of epithelial cells. We quantified early innate responses to Eh in wild-type and MUC-2-deficient mice (Muc2(-/-)) using closed colonic loops. Eh infection in wild-type but not Muc2(-/-) mice induced a time-dependent increase in (3)H-labeled mucin and nonmucin glycoprotein secretions. Immunohistochemical staining revealed intense MUC-2 secretion, which formed a thick, protective mucus plug overlying the surface epithelium, entrapping Eh. In Muc2(-/-) mice, Eh induced a pronounced time-dependent secretory exudate with increased gross pathology scores and serum albumin leakage. Colonic pathology, secretory responses, and increased proinflammatory cytokine secretions of TNF- , IFN-Î³, and IL-13 correlated with altered expression of the tight junction proteins claudin-2, occludin, and ZO-1. We identified the putative Eh virulence factor that elicits the proinflammatory responses and alters tight junction permeability as Eh cysteine protease A5 (EhCP-A5). The present findings demonstrate that colonic mucins confer both luminal and epithelial barrier functions and that, in the absence of MUC-2, mice are more susceptible to Eh-induced secretory and proinflammatory responses mediated by EhCP-A5.
File Format	HTM / HTML
ISSN	00029440
Issue Number	3
Volume Number	182
e-ISSN	15252191
Journal	The American Journal of Pathology
Language	English
Publisher	Elsevier (on behalf of the American Society for Investigative Pathology)
Publisher Date	2013-03-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Blood Cells Research Support, Non-u.s. Gov't Humans Journal Article Tight Junctions Genetics Physiology Colon Goblet Cells Parasitology Inflammation Mediators Intestines Entamoeba Histolytica Secretion Deficiency Mice, Inbred C57bl Gene Expression Regulation Discipline Pathology Epithelial Cells Permeability Metabolism Virulence Factors Mucin-2 Pathogenicity Pathology Animals Tight Junction Proteins Mice
Content Type	Text
Resource Type	Article
Subject	Pathology and Forensic Medicine

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

A281 DOES MUC2 MUCIN REGULATE MUCUS ASSOCIATED PROTEINS AND OTHER GOBLET CELL INNATE DEFENSE MOLECULES?

A198 COLONIC MUC2 MUCIN IS STABILIZED BY FCGBP TO RESIST SALMONELLA TYPHIMURIUM INVASION IN GOBLET CELLS

A288 DISTINCT ROLES IN INNATE HOST DEFENSE AND SUSCEPTIBILITY TO COLONIC INJURY IN MUC2 MUCIN DEFICIENT AND SUFFICIENT MICROBIOTA

Knockout of Ste20-like proline/alanine-rich kinase (SPAK) attenuates intestinal inflammation in mice.

Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel.

Epithelial Cells Expressing EhADH, An Entamoeba histolytica Adhesin, Exhibit Increased Tight Junction Proteins

A85 SEMAPHORIN-3E AMELIORATES INTESTINAL INFLAMMATION BY REGULATING EXPRESSION OF TIGHT JUNCTION PROTEIN AND PROINFLAMMATORY MEDIATORS

The expression of REG 1A and REG 1B is increased during acute amebic colitis.

In situ characterization of O-linked glycans of Muc2 in mouse colon.

Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.

Similar Documents

A281 DOES MUC2 MUCIN REGULATE MUCUS ASSOCIATED PROTEINS AND OTHER GOBLET CELL INNATE DEFENSE MOLECULES?

A198 COLONIC MUC2 MUCIN IS STABILIZED BY FCGBP TO RESIST SALMONELLA TYPHIMURIUM INVASION IN GOBLET CELLS

A288 DISTINCT ROLES IN INNATE HOST DEFENSE AND SUSCEPTIBILITY TO COLONIC INJURY IN MUC2 MUCIN DEFICIENT AND SUFFICIENT MICROBIOTA

Knockout of Ste20-like proline/alanine-rich kinase (SPAK) attenuates intestinal inflammation in mice.

Entamoeba histolytica cysteine proteases cleave the MUC2 mucin in its C-terminal domain and dissolve the protective colonic mucus gel.

Epithelial Cells Expressing EhADH, An Entamoeba histolytica Adhesin, Exhibit Increased Tight Junction Proteins

A85 SEMAPHORIN-3E AMELIORATES INTESTINAL INFLAMMATION BY REGULATING EXPRESSION OF TIGHT JUNCTION PROTEIN AND PROINFLAMMATORY MEDIATORS

The expression of REG 1A and REG 1B is increased during acute amebic colitis.

In situ characterization of O-linked glycans of Muc2 in mouse colon.

Entamoeba histolytica exacerbates epithelial tight junction permeability and proinflammatory responses in Muc2(-/-) mice.