NDLI: Les anti-angiogéniques: de nouveaux standards thérapeutiques dans le cancer du rein métastatique.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cornu, J-N Rouprêt, M. Bensalah, K. Oudard, S. Patard, J-J
Description	Country affiliation: France Author Affiliation: Cornu JN ( Service d'Urologie, Hôpital Pitié-Salpétrière, Assistance Publique-Hôpitaux de Paris, Groupe Hospitalo-Universitaire Est, Faculté de médecine Pierre et Marie Curie, Université Paris VI, Paris, France.)
Abstract	Since 2004, the treatment of metastatic renal cell carcinoma is in deep mutation. Before, the Management was mostly relying on the use of cytokines in association with radical nephrectomy. From 2004, studies of new antiangiogenic molecules, acting on the pVHL-HIF way, VEGF, PDGF or tyrosine-kinase receptors have modified the management of metastatic patients. Antiangiogenic agents improve progression-free survival as shown with sunitinib, in first line treatment, or sorafenib, as second line treatment. The m-TOR inhibitors (Temsirolimus), can be used with a benefit on overall survival in case of poor prognosis renal cell carcinoma or non clear cell carcinoma. Lastly, bevacizumab, an antibody re-combining humanized monoclonal, is able to target VEGF. Side effects are different for each molecule and are not negligible. Nevertheless, the place of these molecules have to be defined in the sequence of the treatment.
File Format	HTM / HTML
ISSN	11667087
Issue Number	Suppl 4
Volume Number	18
Journal	Progr`es en Urologie
Language	French
Publisher	Elsevier
Publisher Date	2008-07-01
Publisher Place	France
Access Restriction	Subscribed
Subject Keyword	Kidney Neoplasms Niacinamide Pyridines Discipline Urology Humans Drug Therapy Pyrroles Phenylurea Compounds Angiogenesis Inhibitors Therapeutic Use Journal Article Pathology Neoplasm Metastasis Indoles Benzenesulfonates Analogs & Derivatives
Alternative Title	Antiangiogenics: new therapeutic standards in metastatic kidney cancer
Content Type	Text
Resource Type	Article
Subject	Urology

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