NDLI: Traitements pharmacologiques de l'hyperactivité vésicale idiopathique: revue de la littérature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Cornu, J. N. Haab, F.
Description	Country affiliation: France Author Affiliation: Cornu JN ( Service d'urologie, université Pierre et Marie Curie-Paris-6, hôpital Tenon, Assistance publique-Hôpitaux de Paris, 4, rue de la Chine, 75020 Paris, France.)
Abstract	OBJECTIVE: To depict the recent advances in the field of pharmacological treatment of idiopathic overactive bladder (iOAB). METHODS: A literature search was conducted, using the PubMed/Medline database. Articles were included if published as full papers, after 2008 and before September 2012, and focused on recent pharmacologic treatment options for iOAB management. Publications having the highest level of evidence have been analyzed to summarize the available evidence, prioritizing the treatments available in France. RESULTS: Some meta-analyses have been published between 2008 and 2012, gathering information about 82 level 1 evidence studies about efficacy and safety of anticholinergics. According to the most recent meta-analysis, anticholinergics have proved their efficacy for iOAB management, reducing the number of micturitions per day by up to 1.59, the number of incontinence episodes per day by up to 0.7, the number of urgency episodes by up to 1.7, the number of urgency incontinence episodes by up to 2.25, and the number of nocturnal voids by up to 0.24. Safety profile was good, especially for solifenacin and fesoterodine, supported by strong scientific evidence. However, data were limited to short-term follow-up, with no anticholinergic drug superior to another. Few data were available about observance, risk factors for failure and results in specific populations. Anticholinergics can be used safely for management of lower urinary tract symptoms in men, but their role is still to be determined. Data about innovative drugs were still preliminary. CONCLUSIONS: Anticholinergics are a valuable option for management of iOAB, and have a growing role in management of lower urinary tract symptoms in men without bladder outlet obstruction.
File Format	HTM / HTML
ISSN	11667087
Issue Number	4
Journal	Progr`es en Urologie
Volume Number	23
Language	French
Publisher	Elsevier
Publisher Date	2013-04-01
Publisher Place	France
Access Restriction	Subscribed
Subject Keyword	Cholinergic Antagonists Urinary Bladder, Overactive Adverse Effects Discipline Urology Humans Drug Therapy Review Therapeutic Use English Abstract Journal Article
Alternative Title	Pharmacological treatment of idiopathic overactive bladder: a literature review
Content Type	Text
Resource Type	Article
Subject	Urology

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