NDLI: Syndrome de Lynch et risque de cancer de la prostate; revue de la littérature.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Maillard, F. Manouvrier, S. Biardeau, X. Ouzzane, A. Villers, A.
Spatial Coverage	France
Description	Author Affiliation: Maillard F ( Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France. Electronic address: fmaillard59@gmail.com.); Manouvrier S ( Service de génétique clinique, hôpital Jeanne-de-Flandre, avenue Eugène-Avinee, 59037 Lille, France); Biardeau X ( Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France. Electronic address: biardeau.xavier@gmail.com.); Ouzzane A ( Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France. Electronic address: adil-ouzzane@orange.fr.); Villers A ( Service d'urologie, hôpital Claude-Huriez, CHRU de Lille, 1, place de Verdun, 59037 Lille cedex, France)
Abstract	INTRODUCTION: The association between Lynch syndrome and prostate cancer has been studied. Recent studies report an association between these two diseases. MATERIAL AND METHODS: Literature review based on PubMed search was performed using the following keywords: Lynch syndrome and prostate cancer. RESULTS: Eight articles analyzing cohorts of subjects carrying Lynch syndrome were analysed including 6786 patients with 175 cancers. Prostate cancers were more frequent with a standardized incidence ratio (SIR) from 0.93 (95% CI: 0.19-2.7) and 5.9 (95% CI 4.1-17.1) and occurs at a younger age than in the general population mainly for mutations in the MSH2 gene. CONCLUSION: Prostate cancer seem more frequent and occur earlier in individuals harboring a mutation in the MSH2 gene while it does not appear to be any difference compared to the general population for other mutations in Lynch syndrome.
File Format	HTM / HTML
ISSN	11667087
Issue Number	5
Volume Number	25
Journal	Progr`es en Urologie
Language	French
Publisher	Elsevier
Publisher Date	2015-04-01
Publisher Place	France
Access Restriction	Subscribed
Subject Keyword	Discipline Urology Complications Humans Risk Factors Male Review Colorectal Neoplasms, Hereditary Nonpolyposis Epidemiology English Abstract Journal Article Incidence Prostatic Neoplasms Evidence-based Medicine Genetics Practice Guidelines As Topic Mutation Diagnosis France Muts Homolog 2 Protein
Alternative Title	Lynch syndrome and risk of prostate cancer; review of the literature
Content Type	Text
Resource Type	Article
Subject	Urology

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