NDLI: Effets de l'obesité sur les résultats anatomopathologiques de la prostatectomie totale et sur la survie sans recidive biologique.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Balssa, L. Pastori, J. Lillaz, J. Panouillères, M. Guichard, G. Bernardini, S. Chabannes, E. Bittard, H. Thiery-Vuillemin, A. Kleinclauss, F.
Description	Country affiliation: France Author Affiliation: Balssa L ( Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France); Pastori J ( Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France); Lillaz J ( Service d'urologie, CHI de Haute-Saône, 25000 Vesoul, France.); Panouillères M ( Université de Franche-Comté, 25000 Besançon, France); Guichard G ( Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France.); Bernardini S ( Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France.); Chabannes E ( Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France.); Bittard H ( Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France); Thiery-Vuillemin A ( Université de Franche-Comté, 25000 Besançon, France); Kleinclauss F ( Service d'urologie et transplantation rénale, CHRU de Besançon, 3, boulevard A.-Fleming, 25030 Besançon, France)
Abstract	OBJECTIVE: To determine whether obesity is associated with adverse pathologic characteristics, positive surgical margins and the biochemical recurrence free survival (bRFS) after primary treatment with radical prostatectomy (RP). PATIENTS AND METHODS: Medical charts of patients managed with RP between 1999 and 2011 for localized prostate cancer (PCa) were retrospectively reviewed. Population study was split into two groups according to the body mass index (BMI): non obese (BMI< 30 kg/m(2)) and obese (BMI ≥ 30 kg/m(2)). Correlations between obesity and adverse pathological features or bRFS were assessed using univariable and multivariable analyses. RESULTS: Overall, 328 patients were included in the present study: 278 (84.8%) obese and 50 (15.2%) non obese. In multivariable analysis, obesity was associated with positive surgical margins (P=0.014), extracapsular extension (P=0.004) and pathologic Gleason score ≥ 7 (P=0.048). Obesity was not associated with seminal vesicle invasion (P=0.636) and lymph node metastasis (P=0.132). After a mean follow-up of 60.51 ± 28.82 months, no statistical difference in terms of bRFS was observed between the two groups (P=0.186). Furthermore, obesity was not an independent predictor of bFS in multivariable analysis. CONCLUSION: Obesity was associated with adverse pathologic characteristics and positive surgical margins but no statistical correlation was found with bRFS. LEVEL OF EVIDENCE: 5.
File Format	HTM / HTML
ISSN	11667087
Issue Number	7
Volume Number	25
Journal	Progr`es en Urologie
Language	French
Publisher	Elsevier
Publisher Date	2015-06-01
Publisher Place	France
Access Restriction	Subscribed
Subject Keyword	Obesity Discipline Urology Complications Humans Middle Aged Neoplasm Recurrence, Local Male Treatment Outcome English Abstract Journal Article Disease-free Survival Prostatic Neoplasms Pathology Etiology Surgery Prostatectomy Aged Retrospective Studies Methods
Alternative Title	Impact of obesity on pathologic outcomes and biochemical reccurence after radical prostatectomy
Content Type	Text
Resource Type	Article
Subject	Urology

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