NDLI: Mise au point sur les classifications moléculaires et la nouvelle classification histologique du cancer de la vessie.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Varinot, J. Furudoï, A. Roupret, M. Compérat, E.
Description	Author Affiliation: Varinot J ( Service d'anatomie et cytologie pathologiques, hôpital La Pitié-Salpêtrière, UPMC Paris VI, 47-83, boulevard de l'Hopital, 75013 Paris, France. Electronic address: justinevarinot@hotmail.com.); Furudoï A ( Service d'anatomie et cytologie pathologiques, hôpital La Pitié-Salpêtrière, UPMC Paris VI, 47-83, boulevard de l'Hopital, 75013 Paris, France.); Roupret M ( Service d'urologie, hôpital La Pitié-Salpêtrière, UPMC Paris VI, 47-83, boulevard de l'Hopital, 75013 Paris, France.); Compérat E ( Service d'anatomie et cytologie pathologiques, hôpital La Pitié-Salpêtrière, UPMC Paris VI, 47-83, boulevard de l'Hopital, 75013 Paris, France.)
Abstract	OBJECTIVE: Comment the new WHO histological classification of tumors of the urinary system and male genital organs 2016 and expose the state of art about urothelial carcinogenesis and molecular modifications of bladder cancer, with the consequences on the treatments. MATERIAL AND METHOD: A systematic review of the literature search was performed from the data base PubMed, focused on the following keywords: 'bladder cancer', 'molecular', 'subtypes'. RESULTS: The new WHO histological classification of tumors of the urinary system 2016 confirm the importance of pathology in determining the care of patients, especially the grade, the histological type and the infiltration, while taking into account the difficulties. In 2014, the Cancer Genome Atlas reported genetic modifications of bladder cancer. Recently, several studies explored molecular anomalies of bladder cancer and elaborated molecular classifications, analyzing their predictive value. According to the groups, different molecular subtype had been defined: Urobasal A, Urobasal B, genomically unstable, infiltrated, squamous cell carcinoma-like and p53-like luminal bladder cancers. This latter subgroup seems to be chemoresistant. CONCLUSIONS: The molecular biology and classifications allow a better understanding of bladder cancer and could complete in near future histological data to improve patient management.
File Format	HTM / HTML
ISSN	11667087
Issue Number	11-12
Journal	Progr`es en Urologie
Volume Number	26
Language	French
Publisher	Elsevier
Publisher Date	2016-09-01
Publisher Place	France
Access Restriction	Subscribed
Subject Keyword	Discipline Urology
Alternative Title	Update on molecular classifications and new histological classification of bladder cancer
Content Type	Text
Resource Type	Article
Subject	Urology

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