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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Pereira, Daniela T. B. Menani, José V. De Luca, Laurival A. |
| Description | Country affiliation: Brazil Author Affiliation: Pereira DT ( Department of Physiology and Pathology, School of Dentistry, Rua Humaitá, 1680, São Paulo State University - UNESP, 14801-903, Araraquara, São Paulo, Brazil.) |
| Abstract | We investigated if a history of FURO/CAP, a protocol that increases brain angiotensin II (ANG II), sensitizes or enhances sodium intake. A subcutaneous injection of the diuretic furosemide (FURO, 10mg/kg) was combined with a converting enzyme inhibitor captopril (CAP, 5mg/kg) to induce a short latency stimulated sodium (0.3M NaCl) and water intake in a 2h FURO/CAP test. Repeated injections of only FURO/CAP, separated by one-week interval, enhanced stimulated and spontaneous (daily) sodium intake. Stimulated fluid intake was completely suppressed when FURO/CAP was combined with two intraperitoneal injections of the ANG II type-1 receptor antagonist losartan (10, 20, or 40 mg/kg each) given within 1h prior to the FURO/CAP test. Losartan reduced by only 35% the FURO/CAP-induced natriuresis. A history of FURO/CAP, FURO/CAP+losartan (all doses), or vehicle produced similar stimulated fluid intake when all animals received only FURO/CAP in the third final FURO/CAP test. However, a history of vehicle or FURO/CAP+losartan 10mg/kg precluded the enhancement in spontaneous sodium intake after the third final FURO/CAP. The FURO/CAP combined with losartan (all doses) also precluded the spontaneous sodium intake enhancement in the weeks that preceded the third final FURO/CAP test. A history of only FURO/CAP, but not vehicle, also enhanced water deprivation-induced sodium appetite. The results suggest that a history of FURO/CAP enhances stimulated and spontaneous sodium intake, as well as water deprivation-induced sodium appetite, and reinforce the role of ANG II as a peptide that mediates long-term effects on behavior. |
| File Format | HTM / HTML |
| ISSN | 00319384 |
| Issue Number | 4 |
| Volume Number | 99 |
| e-ISSN | 1873507X |
| Journal | Physiology & Behavior |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-03-30 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Appetite Research Support, Non-u.s. Gov't Sodium Chloride Captopril Rats Drinking Male Angiotensin-converting Enzyme Inhibitors Pharmacology Metabolism Drug Effects Furosemide Journal Article Behavior, Animal Discipline Physiology Animals Dose-response Relationship, Drug Losartan Diuretics Physiology Water Deprivation Discipline Behavioral Neuroscience Angiotensin Ii Type 1 Receptor Blockers Drug Combinations |
| Content Type | Text |
| Resource Type | Article |
| Subject | Experimental and Cognitive Psychology Behavioral Neuroscience |
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