NDLI: The effect of TNF on food intake and central insulin sensitivity in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	de Kloet, Annette D. Pacheco-López, Gustavo Langhans, Wolfgang Brown, Lynda M.
Description	Country affiliation: United States Author Affiliation: de Kloet AD ( Program in Neuroscience, University of Cincinnati, Cincinnati, OH 45237, United States. dekloead@mail.uc.edu)
Abstract	Circulating and tissue levels of the proinflammatory cytokine tumor necrosis factor (TNF ) are elevated in obesity. TNF interferes with insulin signaling in many tissues and also plays a causal role in the anorexia that accompanies severe challenges to the immune system. The interactions between TNF and insulin in the control of eating are less well known. The present study evaluated the role of TNF in the central nervous system control of food intake by insulin in adult male Long Evans rats. We first determined the ability of several doses of TNF injected into the 3rd cerebral ventricle (i3vt) to reduce food intake in male rats. Subsequently, we assessed the ability of a subthreshold dose of TNF to modulate the effect of i3vt insulin on food intake in male rats fed a low-fat chow or a high-fat (HF) diet. TNF administered i3vt dose-dependently reduced food intake in rats fed a standard low-fat chow diet. Moreover, a low, sub-threshold dose of TNF diminished the reduction in food intake by insulin in rats maintained on a chow diet, but enhanced insulin action in rats maintained on a HF diet. These data suggest that the interaction of TNF with central insulin varies with nutritional and/or dietary conditions.
File Format	HTM / HTML
ISSN	00319384
e-ISSN	1873507X
DOI	10.1016/j.physbeh.2010.11.037
Journal	Physiology & Behavior
Issue Number	1
Volume Number	103
Language	English
Publisher	Elsevier
Publisher Date	2011-04-18
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Body Weight Rats, Long-evans Injections, Intraventricular Insulin Resistance Pharmacology Administration & Dosage Drug Effects Insulin Tumor Necrosis Factor-alpha Behavior, Animal Discipline Physiology Hypoglycemic Agents Animals Dietary Fats Dose-response Relationship, Drug Analysis Of Variance Physiology Discipline Behavioral Neuroscience
Content Type	Text
Resource Type	Article
Subject	Experimental and Cognitive Psychology Behavioral Neuroscience

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