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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Lerman, Jerrold Hammer, Gregory B. Verghese, Susan Ehlers, Melissa Khalil, Samia N. Betts, Eugene Trillo, Raul Deutsch, Jonathan |
| Description | Country affiliation: United States Author Affiliation: Lerman J ( Department of Anesthesia, Women and Children's Hospital of Buffalo, State University of New York at Buffalo, Buffalo, NY 14222, USA. jerrold.lerman@gmail.com) |
| Abstract | BACKGROUND: We sought to characterize the airway responses to desflurane during maintenance of and emergence from anesthesia in children whose airways were supported with laryngeal mask airways (LMAs). METHODS/MATERIALS: Four hundred healthy children were randomized in a 3 : 1 ratio to either desflurane or isoflurane (reference group) during anesthetic maintenance. After induction of anesthesia, anesthesia was maintained with the designated anesthetic. The investigator chose the airway (LMA and facemask), ventilation strategy and when to remove the LMA. The incidence of airway events during maintenance, emergence and recovery was recorded. RESULTS: Ninety percent of children received LMAs. The frequency of major airway events after desflurane (9%) was similar to that after isoflurane (4%) (number needed to harm [NNH] 20), although the frequency of major events after the LMA was removed during deep desflurane anesthesia (15%) was greater than during awake removal (5%) (NNH 10) (P < 0.006) and during deep isoflurane removal (2%) (NNH 8) (P < 0.03). The frequency of airway events of any severity after desflurane was greater than that after isoflurane (39% vs 27%) (P < 0.05). The frequencies of laryngospasm and coughing of any severity after desflurane were greater than those after isoflurane (13% vs 5% and 26% vs 14%, respectively) (P < 0.05). CONCLUSIONS: When an LMA is used during desflurane anesthesia in children, fewer airway events occur when it is removed when the child is awake. Although the time to discharge from recovery was not delayed and no child required overnight admission, caution should be exercised when using an LMA in children who are anesthetized with desflurane. |
| File Format | HTM / HTML |
| ISSN | 11555645 |
| Issue Number | 6 |
| Volume Number | 20 |
| e-ISSN | 14609592 |
| Journal | Pediatric Anesthesia |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2010-06-01 |
| Publisher Place | France |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Comparative Study Age Factors Humans Child, Preschool Double-blind Method Male Epidemiology Journal Article Female Odds Ratio Child Anesthesia, Inhalation Anesthetics, Inhalation Laryngismus Oxygen Adverse Effects Laryngeal Masks Treatment Outcome Administration & Dosage Randomized Controlled Trial Isoflurane Chemically Induced Sample Size Adolescent Anesthesia Recovery Period Discipline Anesthetics Nitrous Oxide Multicenter Study Analysis Of Variance Analogs & Derivatives |
| Content Type | Text |
| Resource Type | Article |
| Subject | Anesthesiology and Pain Medicine Pediatrics, Perinatology and Child Health |
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