NDLI: Intracochlear inflammatory response to cochlear implant electrodes in humans.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seyyedi, Mohammad Nadol, Joseph B.
Description	Country affiliation: United States Author Affiliation: Seyyedi M ( *Department of Otolaryngology, Massachusetts Eye and Ear Infirmary)
Abstract	HYPOTHESIS: This study evaluates the types and degrees of tissue response adjacent to the electrode of multichannel cochlear implants. BACKGROUND: Cochlear implant electrodes have been classified as biocompatible prostheses. Nevertheless, in some reports, electrode extrusion, chronic inflammation, and even soft failure of the implant system have been attributed to a tissue response to the electrode. METHODS: All celloidin-embedded temporal bones with multichannel cochlear implants from the temporal bone collection of the Massachusetts Eye and Ear Infirmary were included in the study. A total of 28 temporal bones from 21 subjects were identified and processed for histology. The severity of cellular response including eosinophil and lymphocytic infiltration, giant cell reaction, new bone formation, and fibrosis were scored on a scale from 0 to 3 at three 1-mm segments along the electrode: first 1 mm at the cochleostomy, last 1 mm from the tip of the electrode, and midway between these proximal and distal segments. The values were compared using the Wilcoxon test. RESULTS: A granulomatous reaction to the electrode was observed in 27 (96.4%) temporal bones. Eosinophil infiltration was observed in 7 (25%) temporal bones, suggesting an allergic reaction. The Inflammatory response to the electrode was significantly greater at the basal turn of cochlea close to the cochleostomy (p < 0.05) than distal to it. CONCLUSION: An inflammatory response is common after cochlear implantation, and it is more robust at the cochleostomy than distal to it, suggesting the role of trauma of insertion as a contributing factor.
File Format	HTM / HTML
ISSN	15317129
e-ISSN	15374505
DOI	10.1097/MAO.0000000000000540
Journal	Otology & Neurotology
Issue Number	9
Volume Number	35
Language	English
Publisher	Lippincott Williams & Wilkins
Publisher Date	2014-10-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, N.i.h., Extramural Adverse Effects Discipline Otolaryngology Inflammation Temporal Bone Pathology Cochlear Implantation Etiology Surgery Cochlea Cochlear Implants Cadaver
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Sensory Systems Neurology (clinical)

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Characterization of intracochlear rupture forces in fresh human cadaveric cochleae.

Surgical trauma after sequential insertion of intracochlear catheters and electrode arrays (a histologic study).

Round window insertion of precurved electrodes is traumatic.

The use of cone-beam computed tomography to determine cochlear implant electrode position in human temporal bones.

Verification of computed tomographic estimates of cochlear implant array position: a micro-CT and histologic analysis.

Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical procedures.

An artificial temporal bone as a training tool for cochlear implantation.

Electro-Mechanical Stimulation of the Cochlea by Vibrating Cochlear Implant Electrodes.

Cochlear Implant Electrode Effect on Sound Energy Transfer Within the Cochlea During Acoustic Stimulation.

Intracochlear inflammatory response to cochlear implant electrodes in humans.

Similar Documents

Characterization of intracochlear rupture forces in fresh human cadaveric cochleae.

Surgical trauma after sequential insertion of intracochlear catheters and electrode arrays (a histologic study).

Round window insertion of precurved electrodes is traumatic.

The use of cone-beam computed tomography to determine cochlear implant electrode position in human temporal bones.

Verification of computed tomographic estimates of cochlear implant array position: a micro-CT and histologic analysis.

Anatomy of the round window and hook region of the cochlea with implications for cochlear implantation and other endocochlear surgical procedures.

An artificial temporal bone as a training tool for cochlear implantation.

Electro-Mechanical Stimulation of the Cochlea by Vibrating Cochlear Implant Electrodes.

Cochlear Implant Electrode Effect on Sound Energy Transfer Within the Cochlea During Acoustic Stimulation.

Intracochlear inflammatory response to cochlear implant electrodes in humans.