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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Husain, Qasim Kanumuri, Vivek V. Svider, Peter F. Radvansky, Brian M. Boghani, Zain Liu, James K. Eloy, Jean Anderson |
| Description | Country affiliation: United States Author Affiliation: Husain Q ( Department of Otolaryngology-Head & Neck Surgery, University of Medicine and Dentistry of New Jersey-New Jersey Medical School, Newark, New Jersey 07103, USA.) |
| Abstract | OBJECTIVE: This study reviews the published outcomes related to sinonasal adenoid cystic carcinoma (SNACC). Clinical presentation, radiographic diagnosis, pathology, treatment, and management outcomes of this uncommon disease are reported. Data Sources PubMed database. METHODS: A systematic review of studies for SNACC from 1960 to 2012 was conducted. A PubMed search for articles related to SNACC, along with bibliographies of those articles, was performed. Articles were examined for both individual patient data (IPD) and aggregate patient data (APD) that reported survivability. Demographics, disease site and spread, treatment strategies, follow-up, outcome, and survival were described for IPD, and a meta-analysis for survival rates was performed for APD. RESULTS: A total of 55 journal articles were included. Individual patient data were reported in 39 journal articles, comprising a total of 88 cases of SNACC. Sixteen articles, totaling 366 patients that reported aggregate 5-year survivorship pertaining to SNACC, were also included. Average follow-up in the IPD was 51.2 months (range, 1-198 months), and 5-year survivorship was 63.5%. In the studies reviewed, surgery followed by postoperative radiotherapy was the most common therapy used and resulted in the highest percentage of survivors. Aggregate patient data meta-analysis revealed a 5-year survival rate of 62.5%. CONCLUSION: This study contains the largest pool of SNACC patients to date. The data suggest that SNACC has a poor overall prognosis. It also suggests that surgery with postoperative radiotherapy is the most commonly used and may possibly be the most effective therapy. |
| File Format | HTM / HTML |
| ISSN | 01945998 |
| Issue Number | 1 |
| Volume Number | 148 |
| e-ISSN | 10976817 |
| Journal | Otolaryngology -- Head and Neck Surgery |
| Language | English |
| Publisher | SAGE Publications |
| Publisher Date | 2013-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Immunohistochemistry Kaplan-meier Estimate Therapy Prognosis Cause Of Death Humans Middle Aged Male Review Journal Article Young Adult Paranasal Sinus Neoplasms Adult Female Retrospective Studies Diagnosis Radiotherapy, Adjuvant Mortality Tomography, X-ray Computed Discipline Otolaryngology Treatment Outcome Combined Modality Therapy Carcinoma, Adenoid Cystic Otorhinolaryngologic Surgical Procedures Disease-free Survival Survival Analysis Aged Biopsy, Needle Neoplasm Staging Methods |
| Content Type | Text |
| Resource Type | Article |
| Subject | Otorhinolaryngology Surgery |
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