NDLI: Association between Magnesium Disorders and Hypocalcemia following Thyroidectomy.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nellis, Jason C. Tufano, Ralph P. Gourin, Christine G.
Description	Country affiliation: United States Author Affiliation: Nellis JC ( Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA.); Tufano RP ( Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA.); Gourin CG ( Department of Otolaryngology-Head and Neck Surgery, Johns Hopkins University, Baltimore, Maryland, USA cgourin1@jhmi.edu.)
Abstract	OBJECTIVE: To identify factors associated with postoperative hypocalcemia after thyroid surgery and to understand the relationship among hypocalcemia, length of hospitalization, and costs of care. STUDY DESIGN: Retrospective database analysis. METHODS: Discharge data from the Nationwide Inpatient Sample for 620,744 patients who underwent thyroid surgery from 2001 to 2010 were analyzed through cross-tabulations and multivariate regression modeling. Hypocalcemia, length of stay, and costs were examined as dependent variables. Secondary independent variables included magnesium and phosphate metabolism disorders, vitamin D deficiency, menopause, sex, extent of surgery, malignancy, and surgeon volume. RESULTS: Hypocalcemia was reported in 6% of patients and was significantly more common for the following variables: women, age <65 years, patients from the Northeast, total thyroidectomy ± neck dissection patients, low-volume surgical care, malignancy, recurrent laryngeal nerve injury, and patients with disorders of magnesium or phosphate metabolism (P < .001). Magnesium and phosphate disorders were present in <1% of patients. Magnesium disorders were significantly more likely for patients with hypocalcemia (7%; P < .001), and hypocalcemia was present in 52% of patients with magnesium disorders (P < .001). On multiple logistic regression analysis, the odds of hypocalcemia were greatest for patients with magnesium disorders (odds ratio, 12.71; 95% confidence interval, 8.59-18.82). This relationship was not attenuated by high-volume surgical care. Hypocalcemia and magnesium disorders were both associated with increased length of stay and costs, with a greater effect for magnesium disorders than for hypocalcemia (P < .001). CONCLUSIONS: Disorders of magnesium metabolism are an independent risk factor for postthyroidectomy hypocalcemia and are associated with significantly increased costs and length of stay.
File Format	HTM / HTML
ISSN	01945998
Issue Number	3
Journal	Otolaryngology -- Head and Neck Surgery
Volume Number	155
e-ISSN	10976817
Language	English
Publisher	SAGE Publications
Publisher Date	2016-09-01
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Otolaryngology
Content Type	Text
Resource Type	Article
Subject	Otorhinolaryngology Surgery

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