NDLI: A felnottkori csontvelobol származó mesenchymalis ossejtek felhasználása sérült szövetek pótlására.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Salamon, Antal Toldy, Erzsébet
Description	Author Affiliation: Salamon A ( Vas Megyei Markusovszky Lajos Altalános és Rehabilitációs Gyógyfürdo Kórház, Egyetemi Oktató Kórház, Baleseti, Helyreállító és Kézsebészeti Osztály, Szombathely. salamon.antal@chello.hu)
Abstract	Mesenchymal stem cells are known as being multipotent and exhibit the potential for differentiation into different cells/tissue lineages, including cartilage, bone, adipose tissue, tendon, and ligament. These pluripotent mesenchymal progenitor cells are denoted as stromal or mesenchymal stem cells. Bone marrow contains two main cell types: hematopoietic cells and stromal cells. The stem cells for non hematopoietic tissues are referred as mesenchymal cells because of their ability to differentiate as mesenchymal or stromal cells. Mesenchymal cells are easily obtainable from bone marrow by means of minimally invasive approach and can be expanded in culture and permitted to differentiate into the desired lineage. The differentiation can be reached by the application of bioactive signaling molecules, specific growth factors. The transforming growth factor beta (TGF-beta) superfamily member proteins such as the bone morphogenetic proteins (BMP-s) are the most important factors of chondrogenic and osteogenic differentiation of mesenchymal stem cells. From the series of recently identified factors, BMP 2,4 and 7 may play an important role in chondrogenic and osteogenic differentiation proteins. Little is known, however, about the signaling pathway involved in tenogenesis of mesenchymal stem cells, but there are some encouraging data about fibroblastic differentiation. The success of growth factor therapy needs a delivery system with biomaterials. Mesenchymal stem cells have become promising vehicles for gene therapy, cell therapy and tissue engineering. In present review, authors deal with the experimental investigations and with the clinical application of the adult bone marrow derived mesenchymal stem cells with bioactive molecules, growth factors.
File Format	HTM / HTML
ISSN	00306002
e-ISSN	17886120
Journal	Orvosi Hetilap
Issue Number	27
Volume Number	150
Language	Hungarian
Publisher	Markusovszky Lajos
Publisher Date	2009-07-05
Publisher Place	Hungary
Access Restriction	Open
Subject Keyword	Genetic Therapy Wounds And Injuries Tendon Injuries Transforming Growth Factor Beta Tissue Scaffolds Mesenchymal Stromal Cells Surgery Discipline Medicine Cell Differentiation Chondrogenesis Adipose Tissue Injuries Tissue Engineering Bone Morphogenetic Protein 4 Bone Morphogenetic Protein 2 Metabolism Bone Marrow Cells Cell- And Tissue-based Therapy Bone Morphogenetic Proteins Ligaments Mesenchymal Stem Cell Transplantation Osteogenesis Bone Morphogenetic Protein 7
Alternative Title	Use of mesenchymal stem cells from adult bone marrow for injured tissue repair
Content Type	Text
Resource Type	Article
Subject	Medicine

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Felnottkori csontvelobol származó mesenchymalis ossejtek szerepe a reparatív folyamatokban.

A mesenchymalis ossejtek szerepe a kéz idegsérüléseinek helyreállításában.

Treatment of irradiated mandibles with mesenchymal stem cells transfected with bone morphogenetic protein 2/7.

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Szövetépítés lehetoségei a kéz hajlítóín-sérüléseinek helyreállításában.

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Response of human embryonic stem cell-derived mesenchymal stem cells to osteogenic factors and architectures of materials during in vitro osteogenesis.

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Mesenchymal stem cell-dependent formation of heterotopic tendon-bone insertions (osteotendinous junctions).

A felnottkori csontvelobol származó mesenchymalis ossejtek felhasználása sérült szövetek pótlására.

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