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Tambouranolide, a new cytotoxic hydroxybutanolide from a Tambourissa sp. (Monimiaceae).
| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Yoder, Brent J. Cao, Shugeng Norris, Andrew Miller, James S. Ratovoson, Fidisoa Andriantsiferana, Rabodo Rasamison, Vincent E. Kingston, David G. I. |
| Description | Country affiliation: United States Author Affiliation: Yoder BJ ( Department of Chemistry, M/C 0212, Virginia Polytechnic Institute and State University, Blacksburg, VA 24061, USA.) |
| Abstract | A new cytotoxic hydroxybutanolide, tambouranolide, has been isolated by solid phase extraction from an ethanol extract of the dried roots of a species of Tambourissa (Monimiaceae) from the Madagascar rainforest. The structure was elucidated through the interpretation of spectral data and its comparison to data reported in the literature for related molecules. The compound showed moderate in vitro cytotoxicity with an IC50 of 8 micro g mL(-1) in the A2780 human ovarian cancer cell line assay. |
| File Format | HTM / HTML |
| ISSN | 14786419 |
| e-ISSN | 14786427 |
| Journal | Natural Product Research |
| Issue Number | 1 |
| Volume Number | 21 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2007-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | Open |
| Subject Keyword | Research Support, N.i.h., Extramural Research Support, Non-u.s. Gov't Discipline Natural products Antineoplastic Agents, Phytogenic Isolation & Purification Discipline Natural Products Pharmacology Monimiaceae Optical Rotation Chemistry Plant Roots Solid Phase Extraction Spectrometry, Mass, Fast Atom Bombardment Cell Line, Tumor Inhibitory Concentration 50 Nuclear Magnetic Resonance, Biomolecular Furans Molecular Structure |
| Content Type | Text |
| Resource Type | Article |
| Subject | Organic Chemistry Plant Science Analytical Chemistry Biochemistry |
