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Antimicrobial and antioxidant activities of a new metabolite from Quercus incana.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gul, Farah Khan, Khalid Mohammed Adhikari, Achyut Zafar, Salman Akram, Muhammad Khan, Haroon Saeed, Muhammad
Description	Country affiliation: Pakistan Author Affiliation: Gul F ( a Department of Pharmacy , University of Peshawar , Peshawar , Pakistan.); Khan KM ( b Pharmacology Section, PCSIR Lab Complex , Peshawar , Pakistan.); Adhikari A ( c H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS) , University of Karachi , Karachi , Pakistan.); Zafar S ( c H.E.J. Research Institute of Chemistry, International Center for Chemical and Biological Sciences (ICCBS) , University of Karachi , Karachi , Pakistan.); Akram M ( d Institute of Chemical Sciences , University of Peshawar , Peshawar , Pakistan.); Khan H ( e Chemistry Section, PCSIR Lab Complex , Peshawar , Pakistan.); Saeed M ( f Department of Pharmacy , Abdul Wali Khan University , Mardan , Pakistan.)
Abstract	Phytochemical investigations of Quercus incana led to the isolation of a new catechin derivative quercuschin (1), along with six known compounds: quercetin (2), methyl gallate (3), gallic acid (4), betulinic acid (5), (Z)-9-octadecenoic acid methyl ester (6) and ß-sitosterol glucoside (7) from the ethyl acetate fraction of methanolic extract of the bark. Compound 1 was screened for its antibacterial, antifungal and antioxidant potential. Antibacterial and antifungal activities of the compound were tested against different bacterial and fungal strains, employing the agar well diffusion methods. The antibacterial activity was the highest against Streptococcus pyogenes with 80.0% inhibition, while the antifungal activity of the compound was the highest against Candida glabrata with 80.5% inhibition. The results of the antioxidant activity indicated that the compound exhibited antioxidant activity comparable to that of standard, butylated hydroxyanisole (51.2 µg/10 µl versus 45.9 µg/10 µl).
File Format	HTM / HTML
ISSN	14786419
Journal	Natural Product Research
e-ISSN	14786427
Language	English
Publisher	Taylor & Francis
Publisher Date	2016-12-21
Publisher Place	Great Britain (UK)
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Natural Products
Content Type	Text
Resource Type	Article
Subject	Organic Chemistry Plant Science Analytical Chemistry Biochemistry

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