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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | López-Saavedra, Alejandro Herrera, Luis A. |
| Description | Country affiliation: Mexico Author Affiliation: López-Saavedra A ( Unidad de Investigación Biomédica en Cáncer, Instituto de Investigaciones Biomédicas, Universidad Nacional Autónoma de México, Instituto Nacional de Cancerología, Mexico.) |
| Abstract | Chromosomal instability (CIN) involves the gain or loss of complete or partial chromosomes during cellular division, and it is a common characteristic of tumors that have aneuploidy. In addition, CIN is considered to be a closely related event to carcinogenesis. The mechanisms that lead to CIN include defects in the cohesion of sister chromatids, mitotic spindle checkpoint, and regulation of the number of centrosomes. Different studies have found that transcription variants, also known as isoforms, which are generated by the alternative splicing of exons and introns in mRNA that encodes many of the regulator proteins of chromosomal segregation, have an important role in mechanisms that lead to CIN. The majority of these isoforms are newly described. The discovery of additional isoforms and the study of their mechanisms of action allow a more integrated view of how cells regulate the segregation of their genetic material, and of how errors occur in chromosomal segregation. |
| File Format | HTM / HTML |
| ISSN | 13835718 |
| e-ISSN | 18793592 |
| Journal | Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Issue Number | 3 |
| Volume Number | 705 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2010-12-01 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Research Support, Non-u.s. Gov't Discipline Genetics Alternative Splicing Rna, Messenger Discipline Biochemistry Aneuploidy Metabolism Neoplasms Spindle Apparatus Animals Ultrastructure Protein Isoforms Sister Chromatid Exchange Genetics Transcription, Genetic Mice Models, Genetic Chromosomal Instability Chromosomes Centrosome |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Health, Toxicology and Mutagenesis |
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