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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Sekeroglu, Zülal Atli Sekeroglu, Vedat |
| Description | Country affiliation: Turkey Author Affiliation: Sekeroglu ZA ( Department of Biology, Ordu University, Ordu, Turkey. sekerogluv@hotmail.com) |
| Abstract | Viscum album, a semi-parasitic plant, has been used both in traditional and supplementary medicine in the treatment of many diseases. Quercetin (QE), one of the major flavonoids in some fruits and vegetables, has anti-oxidative and anti-carcinogenic activities. Methotrexate (MTX), an anti-folate anti-metabolite, is a widely used anti-neoplastic drug with significant clastogenic effects. The aim of this study was to investigate the anti-cytogenotoxic effects of pre-treatment with V. album extract (VAE) and QE on MTX-induced chromosomal aberrations (CAs) in mouse bone-marrow cells. Pre-treatment of mice by gavage with VAE (250mg/kgbw/day for 10 days) and QE (50mg/kgbw/day for 10 days) caused a significant decrease in CAs and in the number of aberrant cells with CAs induced by intramuscular treatment of the mice with MTX (10mg/kgbw/day for 3 days), when compared with the group treated with MTX alone. These compounds also significantly increased the mitotic index (MI) in bone-marrow cells that had been suppressed by MTX. In conclusion, from the findings we suggest that VAE and QE may play a role in reducing cyto-genotoxicity induced by anti-neoplastic drugs during cancer chemotherapy. |
| File Format | HTM / HTML |
| ISSN | 13835718 |
| e-ISSN | 18793592 |
| Journal | Mutation Research/Genetic Toxicology and Environmental Mutagenesis |
| Issue Number | 1 |
| Volume Number | 746 |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2012-07-04 |
| Publisher Place | Netherlands |
| Access Restriction | Open |
| Subject Keyword | Discipline Genetics Toxicity Plant Extracts Discipline Biochemistry Antineoplastic Agents Antimutagenic Agents Pharmacology Viscum Album Drug Effects Dna Damage Mitotic Index Chemistry Bone Marrow Cells Animals Quercetin Mice Methotrexate |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Health, Toxicology and Mutagenesis |
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