NDLI: Effect of vitamin E succinate on the expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor in gastric cancer cells and CD4(+) T cells.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Hou, Liying Zhang, Haijin Xu, Peixiang Zhang, Lijia Zhang, Xuguang Sun, Yanpei Huang, Xiaoli Wu, Kun
Description	Country affiliation: China Author Affiliation: Hou L ( Department of Nutrition and Food Hygiene, School of Public Health, Harbin Medical University, 150081 Harbin, China. wukun_15000@126.com.)
Abstract	Gastric malignancy, which shows poor prognosis, is one of the most frequent causes of cancer-associated deaths. Vitamin E succinate (VES) inhibits cell proliferation and induces apoptosis in a concentration- and time-dependent manner. We explored the effect of VES on the expression of the tumor necrosis factor-related apoptosis-inducing ligand (TRAIL) receptor in gastric cancer cells and CD4(+) T cells. On one hand, VES dose-dependently regulated the expression of the TRAIL receptor in gastric cancer cells. Moreover, the activation of the TRAIL receptor, death receptor 4 (DR4), and death receptor 5 (DR5) in gastric cancer cells increased for up to 12 h. On the other hand, the expression of TRAIL protein in human CD4(+) T cells was obviously upregulated in the presence of VES. On the basis of these findings, we combined VES and human CD4(+) T cells to induce apoptosis of MKN28 human gastric cancer cells. The results showed that VES induced higher gastric cancer cell apoptosis when combined with human CD4(+) T cells than when applied alone. We conclude that VES can induce the expression of TRAIL receptor in gastric cancer cells, as well as the expression of TRAIL in CD4(+) T cells. Overall, our results provide a theoretical basis for future immunotherapy studies.
File Format	HTM / HTML
ISSN	1742206X
Issue Number	11
Volume Number	11
e-ISSN	17422051
Journal	Molecular BioSystems
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2015-11-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Molecular Biology Discipline Biochemistry Cd4-positive T-lymphocytes Metabolism Receptors, Tnf-related Apoptosis-inducing Ligand Stomach Neoplasms Alpha-tocopherol Pharmacology Antineoplastic Agents Apoptosis Drug Effects Cell Line, Tumor Humans Pathology Tnf-related Apoptosis-inducing Ligand Journal Article Research Support, Non-u.s. Gov't
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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