NDLI: Biomolecular proteomics discloses ATP synthase as the main target of the natural glycoside deglucoruscin.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Del Gaudio, Federica Festa, Carmen Mozzicafreddo, Matteo Vasaturo, Michele Casapullo, Agostino De Marino, Simona Riccio, Raffaele Monti, Maria Chiara
Description	Country affiliation: Italy Author Affiliation: Del Gaudio F ( Department of Pharmacy, University of Salerno, Via Giovanni Paolo II, 132, 84084, Fisciano, Italy. mcmonti@unisa.it.)
Abstract	Extracts of Ruscus aculeatus are a rich source of bioactive steroidal glycosides, such as ruscogenins which are reported to act against chronic venous disorders. Nowadays, several preparations of its roots, commonly used in traditional medicine, are on the market as food supplements for health care and maintenance. Although spirostanol deglucoruscin is one of the main metabolites in these extracts, literature reports about its pharmacological profile are scarce. In this paper, a multi-disciplinary approach, based on chemical proteomics, molecular modelling and bio-organic assays, has been used to disclose the whole interactome of deglucoruscin and the F0-F1 ATP synthase complex has been found as its main target.
File Format	HTM / HTML
ISSN	1742206X
Issue Number	10
Journal	Molecular BioSystems
Volume Number	12
e-ISSN	17422051
Language	English
Publisher	Royal Society of Chemistry
Publisher Date	2016-10-20
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Content Type	Text
Resource Type	Article
Subject	Molecular Biology Biotechnology

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