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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Chattopadhyay, Koushik Aldous, Colleen |
| Description | Author Affiliation: Chattopadhyay K ( a Clinical Medicine Laboratory , School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal , Durban , Republic of South Africa.); Aldous C ( a Clinical Medicine Laboratory , School of Clinical Medicine, College of Health Sciences, University of KwaZulu-Natal , Durban , Republic of South Africa.) |
| Abstract | Mitochondrion is a cellular organelle that is present in most of the cells and is responsible for producing energy for the cell. Mitochondria have their own double-stranded DNA genome which is distinct from nuclear genome. The replication, recombination and repair of mtDNA are achieved by DNA polymerase-gamma which is encoded by POLG gene. Mutation in the mtDNA or POLG gene might lead to mitochondrial dysfunction and disease. Several mutations and polymorphisms in these regions have been associated to mitochondrial disorders. Nuceloside and nucelotide reverse transcriptase inhibitors (NRTIs) that form the basis of AIDS therapy have significantly increased the survival rate of HIV-infected individuals predisposing them to other side effects. One of the most common side effects of NRTI usage is mitochondrial toxicity leading to several mitochondrial disorders. Mutations in mtDNA have also been associated to the use of specific NRTIs leading to specific mitochondrial disorders. This review briefly summarizes the advances in mtDNA mutations and NRTI-caused mitochondrial toxicity and mutations. |
| File Format | HTM / HTML |
| ISSN | 19401736 |
| Issue Number | 3 |
| Journal | Mitochondrial DNA |
| Volume Number | 27 |
| e-ISSN | 19401744 |
| Language | English |
| Publisher | Taylor & Francis |
| Publisher Date | 2016-05-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Cell Biology |
| Content Type | Text |
| Resource Type | Article |
| Subject | Genetics Molecular Biology |
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