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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Liao, Fei Dong, Weiguo Fan, Lifang |
| Description | Author Affiliation: Liao F ( Department of Gastroenterology, Renmin Hospital, and Pathology Department, Wuhan University, 99# Zhi yang Road, 430060, Wuhan, Hubei, People's Republic of China.) |
| Abstract | Hepatoma-derived growth factor (HDGF) is a novel multifunctional growth factor that elicits pleiotropic effects on biological processes such as lung remodeling and renal development. Recent studies demonstrated that HDGF is related to tumor proliferation, invasion, angiogenesis, and apoptosis. However, the molecular mechanism of HDGF's involvement in apoptosis remains to be clarified. In this study, we first analyze the role of HDGF in colorectal carcinoma (CRC) progression by immunohistochemistry. Then we used small interference RNA (HDGF-siRNA) to block HDGF and assessed its effect on inducing apoptosis of CRC loVo cells. Apoptosis was detected using flow cytometry (FCM), DNA ladder analysis, and Hoechst 33258 staining. In addition, the expression levels of some apoptosis-related proteins were examined by western blot. The result showed that HDGF expression gradually increased in the colorectal carcinogenesis process. Further studies demonstrated that knock-down of HDGF can down-regulate the survivin, activate the mitochondrial pathway, and induce apoptosis in loVo cells. These findings suggest that HDGF is involved in colorectal carcinogenesis process. Further blocking HDGF exhibits potent pro-apoptotic properties in colon cancer cells. Thus, HDGF might be a potential therapeutic target for human colorectal cancer. These findings may have major implications in the treatment of colorectal cancer. |
| File Format | HTM / HTML |
| ISSN | 13570560 |
| Issue Number | 4 |
| Volume Number | 27 |
| e-ISSN | 1559131X |
| Journal | Medical Oncology |
| Language | English |
| Publisher | Springer |
| Publisher Date | 2010-12-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Cell Proliferation Humans Middle Aged Cytochromes c Male Intercellular Signaling Peptides And Proteins Adenoma Immunoenzyme Techniques Journal Article Flow Cytometry Colorectal Neoplasms Genetics Female Colon Discipline Oncology Rna, Small Interfering Neoplasm Invasiveness Rna, Messenger Lymphatic Metastasis Metabolism Reverse Transcriptase Polymerase Chain Reaction Blotting, Western Pathology Chemistry Rectum Colitis Precancerous Conditions Apoptosis |
| Content Type | Text |
| Resource Type | Article |
| Subject | Hematology Cancer Research Oncology |
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