NDLI: Allogeneic haematopoietic stem cell transplantation as a salvage strategy for relapsed or refractory nasal NK/T-cell lymphoma.

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Allogeneic haematopoietic stem cell transplantation as a salvage strategy for relapsed or refractory nasal NK/T-cell lymphoma.

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Allogeneic haematopoietic stem cell transplantation as a salvage strategy for relapsed or refractory nasal NK/T-cell lymphoma.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Li, Meng Gao, Chunji Li, Honghua Wang, Zhihong Cao, Yongbin Huang, Wenrong Li, Xiaohong Wang, Shuhong Yu, Li Da, Wanming
Description	Country affiliation: China Author Affiliation: Li M ( Department of Hematology, Division of internal medicine, Chinese PLA General Hospital, Fuxing road 28, 100853, Haidian district, Beijing, China.)
Abstract	Nasal NK/T-cell lymphoma is rare and occurs most frequently in East Asia and Latin America. It is characterized by its aggressive nature and tends to become resistant to chemotherapy and radiotherapy. Autologous haematopoietic stem cell transplantation (auto-HSCT) is often associated with a high relapse rate for the active or disseminated disease. There are limited data about allogeneic haematopoietic stem cell transplantation (allo-HSCT) for relapsed or refractory nasal NK/T-cell lymphoma. In our study, two patients with nasal NK/T-cell lymphoma were successfully treated with allo-HSCT. The first patient was a 31-year-old woman who relapsed after auto-HSCT. Subsequently, HLA-matched allo-HSCT was considered as a salvage treatment. Modified BU/CY conditioning regimens included BU/CY/Vm26/Ara-C. Donor lymphocyte infusion was used to reduce the risk of relapse. After allo-HSCT, the tumor in her nasal cavity gradually disappeared. She has been in continuous complete remission (CR) for 3 years. The second patient was a 26-year-old woman diagnosed with stage IIIB advanced nasal NK/T-cell lymphoma who was resistant to combination radiochemotherapy. She underwent HLA-matched allo-HSCT as a salvage treatment. Modified BU/CY conditioning regimens included BU/CY/MeCCNu/Ara-C. She has been in continuous CR for five years. The stem cell source was peripheral blood for both patients, and there was no severe graft-versus-host disease in either patient. Our clinical experience suggests that allo-HSCT with a modified conditioning regimen is a promising treatment for patients with relapsed or refractory nasal NK/T-cell lymphoma.
File Format	HTM / HTML
ISSN	13570560
Issue Number	3
Volume Number	28
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2011-09-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Recurrence Killer Cells, Natural Nose Neoplasms Humans Salvage Therapy Hematopoietic Stem Cell Transplantation Transplantation, Homologous Journal Article Case Reports Pathology Surgery Adult Female Lymphoma, T-cell Discipline Oncology Methods
Content Type	Text
Resource Type	Case study Article
Subject	Hematology Cancer Research Oncology

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