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Discordance and clinical significance of ER, PR, and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yao, Zi-Xiang Lu, Lin-Jie Wang, Rui-Jue Jin, Liang-Bin Liu, Sheng-Chun Li, Hong-Yuan Ren, Guo-Sheng Wu, Kai-Nan Wang, De-Lin Kong, Ling-Quan
Description	Country affiliation: China Author Affiliation: Yao ZX ( Department of Endocrine and Breast Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing, 400016, China.)
Abstract	Discordance of estrogen receptor (ER), progesterone receptor (PR), and human epidermal growth factor receptor 2 (HER2) status between primary breast cancer, metastatic lesion and synchronous axillary lymph node metastasis has been reported in the series studies. Systemic treatment of primary invasive breast cancer patients with synchronous axillary metastasis is currently based on the biomarker characteristics of the primary tumor; however, hormone receptors and HER2 status may change throughout tumor progression from the primary tumor to the synchronous axillary metastasis. As local metastasis, the synchronous axillary lymph node metastasis may represent the potentially metastatic breast cancer cells much better than the primary tumor. Hence, the determination of hormone receptors and HER2 status should be routinely performed in synchronous axillary nodal metastasis, together with primary tumor, to guide therapy management and evaluate the recurrent risk of primary invasive breast cancer patients with synchronous axillary nodal metastasis, which may even change the postoperative risk categories (St. Gallen consensus) of breast cancer in these patients. This article will review the studies on the discordance and clinical significance of ER, PR, and HER2 receptor status between primary breast cancer and synchronous axillary lymph node metastasis.
File Format	HTM / HTML
ISSN	13570560
Issue Number	1
Volume Number	31
e-ISSN	1559131X
Journal	Medical Oncology
Language	English
Publisher	Springer
Publisher Date	2014-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Immunohistochemistry Recurrence Tumor Markers, Biological Receptors, Estrogen Humans Gene Expression Regulation, Neoplastic Risk Gene Expression Profiling Lymphatic Metastasis Review Breast Neoplasms Metabolism Lymph Nodes Journal Article Pathology Receptors, Progesterone Female Receptor, Erbb-2 Discipline Oncology
Content Type	Text
Resource Type	Article
Subject	Hematology Cancer Research Oncology

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Hormone Receptor Status and HER2 Expression in Primary Breast Cancer Compared With Synchronous Axillary Metastases or Recurrent Metastatic Disease.

HER2/neu, Topoisomerase 2a, Estrogen and Progesterone Receptors: Discordance between Primary Breast Cancer and Metastatic Axillary Lymph Node in Expression and Amplification Characteristics

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Az emlorák korszeru patológiai diagnosztikája.

Characteristics of and therapeutic options for contralateral axillary lymph node metastasis in breast cancer.

Establishment and characterization of two human breast carcinoma cell lines by spontaneous immortalization: Discordance between Estrogen, Progesterone and HER2/neu receptors of breast carcinoma tissues with derived cell lines

Systematic review and meta-analysis of breast cancer brain metastasis and primary tumor receptor expression discordance

Triple-negative or HER2-positive status predicts higher rates of locoregional recurrence in node-positive breast cancer patients after mastectomy.

Discordance and clinical significance of ER, PR, and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis.

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Discordance and clinical significance of ER, PR, and HER2 status between primary breast cancer and synchronous axillary lymph node metastasis.