NDLI: Image-guided Radiotherapy Of Esophageal Cancer By Helical Tomotherapy: Acute Toxicity And Preliminary Clinical Outcome

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Palliative Hypofractionated Radiotherapy For Non-Small Cell Lung Cancer (NSCLC) Patients Previously Treated By Induction Chemotherapy: Is It For Many, Some, All, Or None?

Helical tomotherapy for radiochemotherapy in esophageal cancer: a preferred plan?

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Image-guided Radiotherapy Of Esophageal Cancer By Helical Tomotherapy: Acute Toxicity And Preliminary Clinical Outcome

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Image-guided Radiotherapy Of Esophageal Cancer By Helical Tomotherapy: Acute Toxicity And Preliminary Clinical Outcome

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Chen, Yi-Jen Kernstine, Kemp H. Shibata, Stephen Lim, Dean Smith, David D. Tang, Martin Liu, An Pezner, Richard D. Wong, Jeffrey Y. C.
Description	Country affiliation: United States Author Affiliation: Chen YJ ( Divisions of Radiation Oncology (Drs Chen, Liu, Pezner, and Wong, and Martin Tang), Thoracic Surgery (Dr Kernstine), Medical Oncology (Drs Shibata and Lim), Biostatistics (Dr Smith), City of Hope Medical Center, Duarte, CA, USA.)
Abstract	BACKGROUND: Helical tomotherapy is a novel intensity-modulated radiotherapy modality with a helical 360° radiation delivery system and CT imaging ability. The purpose of this report is to review our initial experiences and to assess the toxicity and efficacy of helical tomotherapy for esophageal cancer. METHODS: Twenty patients with locally advanced esophageal cancer (T3-4 and/or N+ and/or M1a/b) were treated with helical tomotherapy. Radiotherapy included simultaneous 50 Gy to gross tumorous areas and 45 Gy to areas of suspected subclinical disease. All received combination chemotherapy. Ten patients underwent surgical resection after completion of chemoradiation. Ten patients were ineligible for surgery. RESULTS: The treatment was well-tolerated. There were no treatment-related deaths or Grade 4 toxicity. Grade 3 toxicities were noted in 9 of 20 patients (45%). Down-staging was noted in 7 of 10 patients (70%) who underwent surgery. The median follow-up time was 24.5 months. Eight patients, including 3 with surgery and 5 without surgery, have died. The 1-year overall survival rates for the entire group, patients with and without surgical resection are 80.0%, 100.0% and 60.0% respectively (log-rank p = 0.244, surgery versus no surgery). CONCLUSIONS: The regimen of combined chemoradiation by helical tomotherapy for locally advanced esophageal cancer is well-tolerated. The toxicity profile compares favorably with that of protocols based on conventional approach and the preliminary indications of efficacy are encouraging.
File Format	HTM / HTML
ISSN	20721439
e-ISSN	20776624
Journal	Journal of Thoracic Diseases
Issue Number	1
Volume Number	1
Language	English
Publisher	AME Publishing Company
Publisher Date	2009-12-01
Publisher Place	China
Access Restriction	Open
Subject Keyword	Discipline Cardiology
Content Type	Text
Resource Type	Article
Subject	Pulmonary and Respiratory Medicine

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