NDLI: Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Edgerton, Dale S. Cherrington, Alan D. Neal, Doss W. Scott, Melanie Lautz, Margaret Brown, Nancy Petro, Jeff Hobbs, Charles H. Leach, Chet Del Parigi, Angelo Strack, Thomas R.
Description	Country affiliation: United States Author Affiliation: Edgerton DS ( Molecular Physiology and Biophysics, Vanderbilt University Medical Center, 710 Robinson Research Building, Nashville, TN 37232-0615, USA. dale.edgerton@vanderbilt.edu)
Abstract	Diabetic patients treated with inhaled insulin exhibit reduced fasting plasma glucose levels. In dogs, insulin action in muscle is enhanced for as long as 3 h after insulin inhalation. This study was designed to determine whether this effect lasts for a prolonged duration such that it could explain the effect observed in diabetic patients. Human insulin was administered via inhalation (Exubera; n = 9) or infusion (Humulin R; n = 9) in dogs using an infusion algorithm that yielded matched plasma insulin kinetics between the two groups. Somatostatin was infused to prevent insulin secretion, and glucagon was infused to replace basal plasma levels of the hormone. Glucose was infused into the portal vein at 4 mg/kg/min and into a peripheral vein to maintain the arterial plasma glucose level at 160 mg/dl. Arterial and hepatic sinusoidal insulin and glucose levels were virtually identical in the two groups. Notwithstanding, glucose utilization was greater when insulin was administered by inhalation. At its peak, the peripheral glucose infusion rate was 4 mg/kg/min greater in the inhalation group, and a 50% difference between groups persisted over 8 h. Inhalation of insulin caused a greater increase in nonhepatic glucose uptake in the first 3 h after inhalation; thereafter, net hepatic glucose uptake was greater. Inhalation of insulin was associated with greater than expected (based on insulin levels) glucose disposal. This may explain the reduced fasting glucose concentrations observed in humans after administration of certain inhaled insulin formulations compared with subcutaneous insulin.
File Format	HTM / HTML
ISSN	00223565
e-ISSN	15210103
DOI	10.1124/jpet.108.146985
Journal	Journal of Pharmacology and Experimental Therapeutics
Issue Number	3
Volume Number	328
Language	English
Publisher	American Society for Pharmacology and Experimental Therapeutics
Publisher Date	2009-03-01
Publisher Place	United States
Access Restriction	Open
Subject Keyword	Research Support, Non-u.s. Gov't Infusion Pumps Liver Drug Therapy Administration, Inhalation Administration & Dosage Glucose Recombinant Proteins Metabolism Diabetes Mellitus Discipline Pharmacology Insulin Drug Effects Therapeutic Use Algorithms Animals Discipline Therapeutics Muscle, Skeletal Pharmacokinetics
Content Type	Text
Resource Type	Article
Subject	Molecular Medicine Pharmacology

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine

A review of inhaled technosphere insulin.

Continuous subcutaneous insulin infusion therapy: A primer on insulin pumps.

Inhaled insulin: concerns remain.

The future of open- and closed-loop insulin delivery systems.

A second-generation inhaled insulin for diabetes mellitus.

Advances in pump technology: insulin patch pumps, combined pumps and glucose sensors, and implanted pumps.

Inhaled insulin: evidence based or industry driven medicine?

Inhaled insulin is approved in Europe and United States.

Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine.

Similar Documents

Inhaled Insulin Is Associated with Prolonged Enhancement of Glucose Disposal in Muscle and Liver in the Canine

A review of inhaled technosphere insulin.

Continuous subcutaneous insulin infusion therapy: A primer on insulin pumps.

Inhaled insulin: concerns remain.

The future of open- and closed-loop insulin delivery systems.

A second-generation inhaled insulin for diabetes mellitus.

Advances in pump technology: insulin patch pumps, combined pumps and glucose sensors, and implanted pumps.

Inhaled insulin: evidence based or industry driven medicine?

Inhaled insulin is approved in Europe and United States.

Inhaled insulin is associated with prolonged enhancement of glucose disposal in muscle and liver in the canine.