NDLI: Estrogen treatment blocks 8-hydroxy-2-dipropylaminotetralin- and apomorphine-induced disruptions of prepulse inhibition: involvement of dopamine D1 or D2 or serotonin 5-HT1A, 5-HT2A, or 5-HT7 receptors.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Gogos, Andrea Kwek, Perrin Chavez, Carolina Van Den Buuse, Maarten
Description	Country affiliation: Australia Author Affiliation: Gogos A ( Behavioral Neuroscience Laboratory, Mental Health Research Institute, 155 Oak St., Parkville (Melbourne), Victoria 3052, Australia.)
Abstract	Prepulse inhibition (PPI) is a measure of sensorimotor gating and an endophenotype of schizophrenia. We have shown previously in rats that estrogen treatment prevents disruption of PPI by the 5-HT(1A)/5-HT(7) receptor agonist 8-hydroxy-2-dipropylaminotetralin (8-OH-DPAT). The aim of the present study was to examine the role of dopamine D(1) and D(2) and serotonin 5-HT(1A), 5-HT(2A), and 5-HT(7) receptors in these effects. Part 1 of this study investigated the ability of estrogen treatment to reverse PPI disruption induced by 8-OH-DPAT or the dopamine D(1)/D(2) receptor agonist apomorphine. Part 2 of this study compared these effects to the ability of various antagonists in reversing the action of 8-OH-DPAT and apomorphine on PPI. Female Sprague-Dawley rats were ovariectomized (OVX), and, where appropriate, they received silastic implants containing either a low (E20) or high dose (E100) of estrogen. Two weeks later, PPI was assessed using automated startle boxes. The disruption of PPI by either treatment with 8-OH-DPAT (0.5 mg/kg) or apomorphine (0.3 mg/kg) was similarly prevented by E100 treatment. 8-OH-DPAT-induced PPI disruption was reversed by pretreatment with the 5-HT(1A) receptor antagonist N-[2-[4-(2-methoxyphenyl)-1-piperazinyl]ethyl]-N-2-pyridinylcyclohexanecarboxamide maleate salt (WAY 100,635; 1 mg/kg) and the typical antipsychotic and dopamine D(2) receptor antagonist haloperidol (0.25 mg/kg), but it was not reversed by pretreatment with the dopamine D(1) receptor antagonist R-(+)-7-chloro-8-hydroxy-3-methyl-1-phenyl-2,3,4,5-tetrahydro-1H-3-benzazepine hydrochloride (SCH 23390; 0.1 mg/kg), the 5-HT(2A/2C) receptor antagonist ketanserin (2 mg/kg), or the 5-HT(7) receptor antagonist SB-269970 (10 mg/kg). Apomorphine-induced disruptions of PPI were reversed by haloperidol and SCH 23390 only. Estrogen may prevent disruptions of PPI induced by both 8-OH-DPAT and apomorphine by an action on dopamine D(2) receptors downstream of 5-HT(1A) receptors.
File Format	HTM / HTML
ISSN	00223565
Issue Number	1
Volume Number	333
e-ISSN	15210103
Journal	Journal of Pharmacology and Experimental Therapeutics
Language	English
Publisher	American Society for Pharmacology and Experimental Therapeutics
Publisher Date	2010-04-01
Publisher Place	United States
Access Restriction	Subscribed
Subject Keyword	Research Support, Non-u.s. Gov't Receptors, Dopamine Toxicity Estrogens Discipline Pharmacology Estradiol Antagonists & Inhibitors Journal Article 8-hydroxy-2-(di-n-propylamino)tetralin Dopamine Agonists Serotonin 5-ht1 Receptor Antagonists Dose-response Relationship, Drug Reflex, Startle Female Physiology Receptor, Serotonin, 5-ht2a Ovariectomy Serotonin Receptor Agonists Receptors, Serotonin Rats Rats, Sprague-dawley Serotonin 5-ht1 Receptor Agonists Pharmacology Drug Effects Apomorphine Receptors, Dopamine D1 Animals Discipline Therapeutics Serotonin 5-ht2 Receptor Antagonists Receptors, Dopamine D2 Agonists Dopamine D2 Receptor Antagonists Receptor, Serotonin, 5-ht1a
Content Type	Text
Resource Type	Article
Subject	Molecular Medicine Pharmacology

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