NDLI: Villitis of unknown aetiology: correlation of recurrence with clinical outcome.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Feeley, L. Mooney, E. E.
Description	Country affiliation: Ireland Author Affiliation: Feeley L ( Department of Pathology and Laboratory Medicine, National Maternity Hospital, Dublin, Ireland.)
Abstract	Villitis of unknown aetiology (VUA) is associated with adverse pregnancy outcome. Consequently, an ability to predict recurrence could be clinically relevant. We examined placentas where villitis was diagnosed in a previous pregnancy to establish the risk of recurrence and outcome. A total of 304 cases of VUA were diagnosed in our laboratory over a 4-year period. Subsequently, 19 of this cohort had a second placenta examined histologically. Recurrence and clinical outcome were recorded. Villitis recurred in 7 of 19 cases (37%). There was a high level of adverse pregnancy outcome in this cohort overall, characterised by small for gestational age infants and stillbirth, particularly in cases with high-grade villitis. We identified recurrent villitis more frequently than previously reported. Our findings confirm an association between high-grade villitis and poor outcome. Adequately powered prospective studies are required to determine if enhanced surveillance of subsequent pregnancies is indicated following a diagnosis of villitis.
File Format	HTM / HTML
ISSN	01443615
Issue Number	5
Volume Number	30
e-ISSN	13646893
Journal	Journal of Obstetrics and Gynaecology
Language	English
Publisher	Taylor & Francis
Publisher Date	2010-01-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Recurrence Humans Risk Factors Discipline Obstetrics Male Inflammation Placenta Diseases Epidemiology Journal Article Pregnancy Birth Weight Pathology Immunology Female Chorionic Villi Discipline Gynaecology Pregnancy Outcome Infant, Newborn Cohort Studies
Content Type	Text
Resource Type	Article
Subject	Obstetrics and Gynecology

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