NDLI: The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.

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The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Setchell, Kenneth D. R. Zhao, Xueheng Shoaf, Susan E. Ragland, Karen
Description	Country affiliation: United States Author Affiliation: Setchell KD ( Division of Pathology and Laboratory Medicine, Department of Pediatrics, Cincinnati Children's Hospital Medical Center, Cincinnati, OH 45229, USA. kenneth.setchell@cchmc.org)
Abstract	The soy isoflavone metabolite, S-(-)equol, has selective affinity for estrogen receptor (ER)beta and also antagonizes in vivo the action of dihydrotestosterone. It is therefore of interest as a potential new therapeutic agent in hormone-dependent conditions and is under development as a nutraceutical. Our objective in this study was to define the pharmacokinetics of natural S-(-)equol after administration of SE5-OH, a newly developed S-(-)equol supplement made by incubation of the equol-producing bacterium Lactococcus garvieae with soy germ isoflavones. In a single-center, open-label, randomized, 2-period crossover design study, the pharmacokinetics of S-(-)equol administered as single-bolus oral doses of 10 and 30 mg in the form of SE5-OH tablets was determined in 12 healthy postmenopausal women. S-(-)equol was measured in plasma and urine collected at timed intervals over a 48-h period postdosing using tandem MS. Equol-producer status was also determined after a soymilk challenge conducted after the pharmacokinetic sampling was complete. S-(-)equol was rapidly absorbed after oral administration and attained high plasma concentrations, with a plasma elimination half-life of 8 h. The maximum plasma concentration/dose, area under the plasma concentration-time curve from time 0 to infinity/dose, and the fraction of dose excreted in urine (%f(e,u)) were similar for the 2 doses, indicating a dose-proportional response in total S-(-)equol pharmacokinetics. The systemic bioavailability of S-(-)equol was very high, as the %f(e,u) was 82% for both doses, which is greater than published data for the soy isoflavones daidzein and genistein. Three participants were determined to be equol-producers, representing a 25% frequency, and equol-producer status had no effect on natural S-(-)equol pharmacokinetics.
File Format	HTM / HTML
ISSN	00223166
Issue Number	11
Volume Number	139
e-ISSN	15416100
Journal	Journal of Nutrition
Language	English
Publisher	American Society for Nutrition
Publisher Date	2009-11-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Body Mass Index Urine Research Support, Non-u.s. Gov't Tablets Administration, Oral Cross-over Studies Humans Middle Aged Equol Reference Values Follicle Stimulating Hormone Administration & Dosage Randomized Controlled Trial Estradiol Blood Journal Article Inpatients Postmenopause Female Aged Discipline Nutrition Pharmacokinetics Isoflavones
Content Type	Text
Resource Type	Article
Subject	Nutrition and Dietetics Medicine

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S-equol and the fermented soy product SE5-OH containing S-equol similarly decrease ovariectomy-induced increase in rat tail skin temperature in an animal model of hot flushes.

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Weight loss increases follicle stimulating hormone in overweight postmenopausal women [corrected].

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The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.

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The pharmacokinetics of S-(-)equol administered as SE5-OH tablets to healthy postmenopausal women.