NDLI: Plasmacytoid dendritic cells and Toll-like receptor 7-dependent signalling promote efficient protection of mice against highly virulent influenza A virus.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kaminski, Michael M. Ohnemus, Annette Cornitescu, Marius Staeheli, Peter
Description	Country affiliation: Germany Author Affiliation: Kaminski MM ( Department of Virology, University of Freiburg, D-79104 Freiburg, Germany.)
Abstract	Types I and III interferons (IFNs) elicit protective antiviral immune responses during influenza virus infection. Although many cell types can synthesize IFN in response to virus infection, it remains unclear which IFN sources contribute to antiviral protection in vivo. We found that mice carrying functional alleles of the Mx1 influenza virus resistance gene partially lost resistance to infection with a highly pathogenic H7N7 influenza A virus strain if Toll-like receptor 7 (TLR7) signalling was compromised. This effect was achieved by deleting either the TLR7 gene or the gene encoding the TLR7 adaptor molecule MyD88. A similar decrease of influenza virus resistance was observed when animals were deprived of plasmacytoid dendritic cells (pDCs) at day 1 post-infection. Our results provide in vivo proof that pDCs contribute to the protection of the lung against influenza A virus infections, presumably via signals from TLR7.
File Format	HTM / HTML
ISSN	00221317
Issue Number	Pt 3
Volume Number	93
e-ISSN	14652099
Journal	Journal of General Virology
Language	English
Publisher	Microbiology Society
Publisher Date	2012-03-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Research Support, Non-u.s. Gov't Dendritic Cells Disease Resistance Signal Transduction Discipline Virology Male Myeloid Differentiation Factor 88 Journal Article Influenza A Virus, H7n7 Subtype Pathogenicity Immunology Animals Gene Deletion Female Genetics Orthomyxoviridae Infections Mice Membrane Glycoproteins Toll-like Receptor 7
Content Type	Text
Resource Type	Article
Subject	Virology

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