NDLI: Complete coding sequence and molecular epidemiological analysis of Sindbis virus isolates from mosquitoes and humans, Finland.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Sane, Jussi Kurkela, Satu Putkuri, Niina Huhtamo, Eili Vaheri, Antti Vapalahti, Olli
Spatial Coverage	Finland
Description	Country affiliation: Finland Author Affiliation: Sane J ( Infection Biology Research Program, Department of Virology, Haartman Institute, Faculty of Medicine, PO Box 21, FI-00014 University of Helsinki, Helsinki, Finland. jussi.sane@helsinki.fi)
Abstract	Sindbis virus (SINV) is an arthropod-borne alphavirus, which causes rash-arthritis, particularly in Finland. SINV is transmitted by mosquitoes in Finland but thus far no virus has been isolated from mosquitoes. In this study, we report the isolation of the first SINV strain from mosquitoes in Finland and its full-length protein-coding sequence. We furthermore describe the full-length coding sequence of six SINV strains previously isolated from humans in Finland and from a mosquito in Russia. The strain isolated from mosquitoes (Ilomantsi-2005M) was very closely related to all the other Northern European SINV strains. We found 9 aa positions, of which five in the nsP3 protein C terminus, to be distinctive signatures for the Northern European strains that may be associated with vector or host species adaptation. Phylogenetic analyses further indicate that SINV has a local circulation in endemic regions in Northern Europe and no novel strains are frequently being introduced.
File Format	HTM / HTML
ISSN	00221317
Issue Number	Pt 9
Volume Number	93
e-ISSN	14652099
Journal	Journal of General Virology
Language	English
Publisher	Microbiology Society
Publisher Date	2012-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Amino Acid Sequence Cell Line Research Support, Non-u.s. Gov't Insect Vectors Discipline Virology Humans Open Reading Frames Isolation & Purification Molecular Sequence Data Phylogeny Epidemiology Journal Article Virology Sindbis Virus Animals Alphavirus Infections Culicidae Finland Classification Genetics
Content Type	Text
Resource Type	Article
Subject	Virology

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