NDLI: Human cytomegalovirus suppresses Fas expression and function.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Seirafian, Sepehr Prod'homme, Virginie Sugrue, Daniel Davies, James Fielding, Ceri Tomasec, Peter Wilkinson, Gavin W. G.
Description	Country affiliation: United kingdom Author Affiliation: Seirafian S ( Institute of Infection & Immunity, Cardiff University School of Medicine, Heath Park, Cardiff CF14 4XN, UK.)
Abstract	Human cytomegalovirus (HCMV) is known to evade extrinsic pro-apoptotic pathways not only by downregulating cell surface expression of the death receptors TNFR1, TRAIL receptor 1 (TNFRSF10A) and TRAIL receptor 2 (TNFRSF10B), but also by impeding downstream signalling events. Fas (CD95/APO-1/TNFRSF6) also plays a prominent role in apoptotic clearance of virus-infected cells, so its fate in HCMV-infected cells needs to be addressed. Here, we show that cell surface expression of Fas was suppressed in HCMV-infected fibroblasts from 24 h onwards through the late phase of productive infection, and was dependent on de novo virus-encoded gene expression but not virus DNA replication. Significant levels of the fully glycosylated (endoglycosidase-H-resistant) Fas were retained within HCMV-infected cells throughout the infection within intracellular membranous structures. HCMV infection provided cells with a high level of protection against Fas-mediated apoptosis. Downregulation of Fas was observed with HCMV strains AD169, FIX, Merlin and TB40.
File Format	HTM / HTML
ISSN	00221317
e-ISSN	14652099
DOI	10.1099/vir.0.058313-0
Journal	Journal of General Virology
Issue Number	Pt 4
Volume Number	95
Language	English
Publisher	Microbiology Society
Publisher Date	2014-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Cytomegalovirus Research Support, Non-u.s. Gov't Discipline Virology Cells, Cultured Antigens, Cd95 Antagonists & Inhibitors Virology Immunology Host-pathogen Interactions Immune Evasion Fibroblasts Physiology
Content Type	Text
Resource Type	Article
Subject	Virology

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1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
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