NDLI: Characterization of a novel insect-specific flavivirus from Brazil: potential for inhibition of infection of arthropod cells with medically important flaviviruses.

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Characterization of a novel insect-specific flavivirus from Brazil: potential for inhibition of infection of arthropod cells with medically important flaviviruses.

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Characterization of a novel insect-specific flavivirus from Brazil: potential for inhibition of infection of arthropod cells with medically important flaviviruses.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Kenney, Joan L. Solberg, Owen D. Langevin, Stanley A. Brault, Aaron C.
Spatial Coverage	Brazil
Description	Country affiliation: United States Author Affiliation: Kenney JL ( Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA.); Solberg OD ( Sandia National Laboratories, Livermore, CA, USA.); Langevin SA ( Sandia National Laboratories, Livermore, CA, USA.); Brault AC ( Division of Vector-Borne Diseases, Centers for Disease Control and Prevention, Fort Collins, CO 80521, USA abrault@cdc.gov.)
Abstract	In the past decade, there has been an upsurge in the number of newly described insect-specific flaviviruses isolated pan-globally. We recently described the isolation of a novel flavivirus (tentatively designated 'Nhumirim virus'; NHUV) that represents an example of a unique subset of apparently insect-specific viruses that phylogenetically affiliate with dual-host mosquito-borne flaviviruses despite appearing to be limited to replication in mosquito cells. We characterized the in vitro growth potential and 3' untranslated region (UTR) sequence homology with alternative flaviviruses, and evaluated the virus's capacity to suppress replication of representative Culex spp.-vectored pathogenic flaviviruses in mosquito cells. Only mosquito cell lines were found to support NHUV replication, further reinforcing the insect-specific phenotype of this virus. Analysis of the sequence and predicted RNA secondary structures of the 3' UTR indicated NHUV to be most similar to viruses within the yellow fever serogroup and Japanese encephalitis serogroup, and viruses in the tick-borne flavivirus clade. NHUV was found to share the fewest conserved sequence elements when compared with traditional insect-specific flaviviruses. This suggests that, despite apparently being insect specific, this virus probably diverged from an ancestral mosquito-borne flavivirus. Co-infection experiments indicated that prior or concurrent infection of mosquito cells with NHUV resulted in a significant reduction in virus production of West Nile virus (WNV), St Louis encephalitis virus (SLEV) and Japanese encephalitis virus. The inhibitory effect was most effective against WNV and SLEV with over a 10(6)-fold and 10(4)-fold reduction in peak titres, respectively.
File Format	HTM / HTML
ISSN	00221317
e-ISSN	14652099
DOI	10.1099/vir.0.068031-0
Journal	Journal of General Virology
Issue Number	Pt 12
Volume Number	95
Language	English
Publisher	Microbiology Society
Publisher Date	2014-12-01
Publisher Place	Great Britain (UK)
Access Restriction	Open
Subject Keyword	Research Support, U.s. Gov't, Non-p.h.s. Amino Acid Sequence Cell Line Discipline Virology Cytology Isolation & Purification Molecular Sequence Data Viral Proteins Phylogeny Metabolism Flavivirus Research Support, U.s. Gov't, P.h.s. Animals Virus Replication Gene Expression Regulation, Viral Culicidae Genetics
Content Type	Text
Resource Type	Article
Subject	Virology

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