NDLI: Evidence for an intranasal immune response to human respiratory syncytial virus infection in cynomolgus macaques.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Grandin, Clément Lucas-Hourani, Marianne Clavel, Marine Taborik, Fabrice Vabret, Astrid Tangy, Frédéric Contamin, Hugues Vidalain, Pierre-Olivier
Description	Country affiliation: France Author Affiliation: Grandin C ( Cynbiose SA, Marcy-l'Etoile, France Institut Pasteur, Unité de Génomique Virale et Vaccination, Paris, France CNRS, UMR3569, Paris, France.); Lucas-Hourani M ( Institut Pasteur, Unité de Génomique Virale et Vaccination, Paris, France CNRS, UMR3569, Paris, France.); Clavel M ( Cynbiose SA, Marcy-l'Etoile, France.); Taborik F ( Cynbiose SA, Marcy-l'Etoile, France.); Vabret A ( Université de Caen-Basse-Normandie, EA 4655-U2RM, Laboratoire de Virologie, CHU de Caen, France.); Tangy F ( Institut Pasteur, Unité de Génomique Virale et Vaccination, Paris, France CNRS, UMR3569, Paris, France pierre-olivier.vidalain@pasteur.fr frédéric.tangy@pasteur.fr hugues.contamin@cynbiose.com.); Contamin H ( Cynbiose SA, Marcy-l'Etoile, France pierre-olivier.vidalain@pasteur.fr frédéric.tangy@pasteur.fr hugues.contamin@cynbiose.com.); Vidalain PO ( Institut Pasteur, Unité de Génomique Virale et Vaccination, Paris, France CNRS, UMR3569, Paris, France pierre-olivier.vidalain@pasteur.fr frédéric.tangy@pasteur.fr hugues.contamin@cynbiose.com.)
Abstract	There is no large-scale therapy available against human respiratory syncytial virus (hRSV), a major pathogen responsible for acute respiratory diseases. Macaques represent an interesting animal model to evaluate potential treatments because of their genetic, anatomical and immunological proximity with humans. However, the parameters that influence hRSV growth and control in this model are still poorly understood. We have documented in the following study the influence of age as well as repeated infections on the virological, clinical and immunological parameters of this animal model. Following intranasal inoculation, hRSV replicated in the upper respiratory tract for less than 15 days with no clinical signs regardless of age. Interestingly, we observed the induction of a local immune response at the nasal mucosa as assessed by expression profiles of inflammatory and IFN-stimulated genes. Animals also developed specific antibodies and were immune to reinfection. Thus, we showed that even in infant macaques, intranasal hRSV infection induced both local and systemic immune responses to efficiently control the virus.
File Format	HTM / HTML
ISSN	00221317
Issue Number	Pt 4
Volume Number	96
e-ISSN	14652099
Journal	Journal of General Virology
Language	English
Publisher	Microbiology Society
Publisher Date	2015-04-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Cell Line Research Support, Non-u.s. Gov't Age Factors Discipline Virology Interferons Humans Respiratory Syncytial Virus, Human Nasal Mucosa Male Respiratory Tract Infections Antibodies, Viral Administration, Intranasal Respiratory Syncytial Virus Infections Journal Article Virology Pregnancy Immunology Animals Virus Replication Female Macaca Fascicularis Methods Disease Models, Animal
Content Type	Text
Resource Type	Article
Subject	Virology

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