NDLI: Late stages of the influenza A virus replication cycle-a tight interplay between virus and host.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Pohl, Marie O. Lanz, Caroline Stertz, Silke
Description	Country affiliation: Switzerland Author Affiliation: Pohl MO ( 1â Institute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.); Lanz C ( 1â Institute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.); Stertz S ( 1â Institute of Medical Virology, University of Zurich, 8057 Zurich, Switzerland.)
Abstract	After successful infection and replication of its genome in the nucleus of the host cell, influenza A virus faces several challenges before newly assembled viral particles can bud off from the plasma membrane, giving rise to a new infectious virus. The viral ribonucleoprotein (vRNP) complexes need to exit from the nucleus and be transported to the virus assembly sites at the plasma membrane. Moreover, they need to be bundled to ensure the incorporation of precisely one of each of the eight viral genome segments into newly formed viral particles. Similarly, viral envelope glycoproteins and other viral structural proteins need to be targeted to virus assembly sites for viral particles to form and bud off from the plasma membrane. During all these steps influenza A virus heavily relies on a tight interplay with its host, exploiting host-cell proteins for its own purposes. In this review, we summarize current knowledge on late stages of the influenza virus replication cycle, focusing on the role of host-cell proteins involved in this process.
File Format	HTM / HTML
ISSN	00221317
Issue Number	9
Journal	Journal of General Virology
Volume Number	97
e-ISSN	14652099
Language	English
Publisher	Microbiology Society
Publisher Date	2016-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Discipline Virology
Content Type	Text
Resource Type	Article
Subject	Virology

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