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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Mirza, Eraj Humayun Pan-Pan, Chong Wan Ibrahim, Wan Mohd Azhar Bin Djordjevic, Ivan Pingguan-Murphy, Belinda |
| Description | Country affiliation: Malaysia Author Affiliation: Mirza EH ( Faculty of Engineering, Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, 50603, Kuala Lumpur, Malaysia.); Pan-Pan C ( Department of Biomedical Technology, College of Applied Medical Sciences, King Saud University, Riyadh, Kingdom of Saudi Arabia.); Wan Ibrahim WM ( Faculty of Medicine, Department of Orthopaedic Surgery, Tissue Engineering Group (TEG), National Orthopaedic Centre of Excellence for Research and Learning (NOCERAL), University of Malaya, 50603, Kuala Lumpur, Malaysia.); Djordjevic I ( Faculty of Engineering, Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, 50603, Kuala Lumpur, Malaysia.); Pingguan-Murphy B ( Faculty of Engineering, Department of Biomedical Engineering, University of Malaya, Kuala Lumpur, 50603, Kuala Lumpur, Malaysia.) |
| Abstract | Articular cartilage is a tissue specifically adapted to a specific niche with a low oxygen tension (hypoxia), and the presence of such conditions is a key factor in regulating growth and survival of chondrocytes. Zinc deficiency has been linked to cartilage-related disease, and presence of Zinc is known to provide antibacterial benefits, which makes its inclusion attractive in an in vitro system to reduce infection. Inclusion of 1% zinc oxide nanoparticles (ZnONP) in poly octanediol citrate (POC) polymer cultured in hypoxia has not been well determined. In this study we investigated the effects of ZnONP on chondrocyte proliferation and matrix synthesis cultured under normoxia (21% $O_{2})$ and hypoxia (5% $O_{2}).$ We report an upregulation of chondrocyte proliferation and sulfated glycosaminoglycan (S-GAG) in hypoxic culture. Results demonstrate a synergistic effect of oxygen concentration and 1% ZnONP in up-regulation of anabolic gene expression (Type II collagen and aggrecan), and a down regulation of catabolic (MMP-13) gene expression. Furthermore, production of transcription factor hypoxia-inducible factor 1A (HIF-1A) in response to hypoxic condition to regulate chondrocyte survival under hypoxia is not affected by the presence of 1% ZnONP. Presence of 1% ZnONP appears to act to preserve homeostasis of cartilage in its hypoxic environment. © 2015 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 103A: 3554–3563, 2015. |
| File Format | HTM / HTML |
| ISSN | 15493296 |
| Issue Number | 11 |
| Volume Number | 103 |
| e-ISSN | 15524965 |
| Journal | Journal of Biomedical Materials Research Part A |
| Language | English |
| Publisher | Wiley |
| Publisher Date | 2015-11-01 |
| Publisher Place | United States |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Research Support, Non-u.s. Gov't Cell Proliferation Cytology Fluorescence Journal Article Nanoparticles Cell Hypoxia Tissue Scaffolds Cattle Ultrastructure Cartilage, Articular Genetics Cytoprotection Proteoglycans Extracellular Matrix Cell Survival Rna, Messenger Gene Expression Regulation Pharmacology Metabolism Drug Effects Discipline Biomedical Engineering Chemistry Animals Dna Chondrocytes Zinc Oxide |
| Content Type | Text |
| Resource Type | Article |
| Subject | Ceramics and Composites Metals and Alloys Biomaterials Biomedical Engineering |
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