NDLI: Anti-CD34 antibodies immobilized on the surface of sirolimus-eluting stents enhance stent endothelialization.

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Anti-CD34 antibodies immobilized on the surface of sirolimus-eluting stents enhance stent endothelialization.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Nakazawa, Gaku Granada, Juan F. Alviar, Carlos L. Tellez, Armando Kaluza, Greg L. Guilhermier, Margaret Yoklavich Parker, Sherry Rowland, Stephen M. Kolodgie, Frank D. Leon, Martin B. Virmani, Renu
Description	Author Affiliation: Nakazawa G ( CVPath Institute, Inc, Gaithersburg, Maryland.)
Abstract	OBJECTIVES: In this study, we hypothesized that an antihuman-CD34 antibody immobilized on the surface of commercially available sirolimus-eluting stents (SES) could enhance re-endothelialization compared with SES alone. BACKGROUND: Previous experience with antihuman-CD34 antibody surface modified Genous stents (GS) (OrbusNeich Medical, Fort Lauderdale, Florida) has shown enhanced stent endothelialization in vivo. METHODS: In the phase 1 study, stents were deployed in 21 pig coronary arteries for single stenting (9 vessels: 3 GS, 3 SES, and 3 bare-metal stents) and overlapping stenting with various combinations (12 vessels: 4 GS+GS, 4 SES+SES, and 4 GS+SES) and harvested at 14 days for scanning electron and confocal microscopy. In phase 2, immobilized anti-CD34 antibody coating was applied on commercially available SES (SES-anti-CD34, n = 7) and compared with GS (n = 8) and SES (n = 7) and examined at 3 and 14 days by scanning electron/confocal microscopy analysis. RESULTS: In phase 1, single stent implantation showed greatest endothelialization in GS (99%) and in bare-metal stent (99%) compared with SES (55%, p = 0.048). In overlapping stents, endothelialization at the overlapping zone was significantly greater in GS+GS (95 +/- 6%) and GS+SES (79 +/- 5%) compared with the SES+SES (36 +/- 14%) group (p = 0.007). In phase 2, SES-anti-CD34 resulted in increased endothelialization compared with SES alone at 3 days (SES-anti-CD34 36 +/- 26%; SES 7 +/- 3%; and GS 76 +/- 8%; p = 0.01), and 14 days (SES-anti-CD34 82 +/- 8%; SES 53 +/- 20%; and GS 98 +/- 2%; p = 0.009). CONCLUSIONS: Immobilization of anti-CD34 antibody on SES enhances endothelialization and may potentially be an effective therapeutic alternative to improve currently available drug-eluting stents.
File Format	HTM / HTML
ISSN	19368798
Issue Number	1
Volume Number	3
e-ISSN	18767605
Journal	JACC: Cardiovascular Interventions
Language	English
Publisher	Elsevier
Publisher Date	2010-01-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Research Support, Non-u.s. Gov't Endothelial Cells Cell Proliferation Comparative Study Sirolimus Humans Metals Antibodies Instrumentation Cardiovascular Agents Drug-eluting Stents Prosthesis Design Journal Article Angioplasty, Balloon, Coronary Immunology Time Factors Etiology Ultrastructure Swine Discipline Cardiology Dose-response Relationship, Drug Models, Animal Stents Antigens, Cd34 Microscopy, Electron, Scanning Adverse Effects Prevention & Control Cells, Cultured Coronary Restenosis Treatment Outcome Administration & Dosage Drug Effects Microscopy, Confocal Animals
Content Type	Text
Resource Type	Article
Subject	Cardiology and Cardiovascular Medicine

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