NDLI: Intravesical hyaluronic acid treatment improves bacterial cystitis and reduces cystitis-induced hypercontractility in rats.

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Intravesical hyaluronic acid treatment improves bacterial cystitis and reduces cystitis-induced hypercontractility in rats.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Yildiz, Nurdan Alpay, Harika Tugtepe, Halil Özdemir Kumral, Zarife Nigar Akakin, Dilek Ilki, Arzu Sener, Göksel Yegen, Berrak Ç.
Description	Country affiliation: Turkey Author Affiliation: Yildiz N ( Department of Pediatric Nephrology, Marmara University School of Medicine, Istanbul, Turkey.); Alpay H ( Department of Pediatric Nephrology, Marmara University School of Medicine, Istanbul, Turkey.); Tugtepe H ( Department of Pediatric Surgery, Marmara University School of Medicine, Istanbul, Turkey.); Özdemir Kumral ZN ( Department of Physiology, Marmara University School of Medicine, Istanbul, Turkey.); Akakin D ( Department of Histology and Embryology, Marmara University School of Medicine, Istanbul, Turkey.); Ilki A ( Department of Microbiology, Marmara University School of Medicine, Istanbul, Turkey.); Sener G ( Department of Pharmacology, Marmara University School of Pharmacy, Istanbul, Turkey.); Ç Yegen B ( Department of Physiology, Marmara University School of Medicine, Istanbul, Turkey.)
Abstract	OBJECTIVE: To investigate the effect of intravesical hyaluronic acid on Escherichia coli-induced cystitis and cystitis-induced hypercontractility in rats. METHODS: Bacterial cystitis was induced in Wistar female rats by intravesical inoculation of E. coli. Isotonic saline was instilled in the control group (n = 6). The rats were either non-treated, treated with gentamycin (4 mg/kg, 5 days) or treated intravesically with hyaluronic acid (0.5 mL, 0.5%). On the eighth day, the bladder tissues were excised for histological examination, and the measurements of myeloperoxidase, superoxide dismutase and catalase activities. Contraction/relaxation responses to carbachol, isoprotrenol and papaverine were studied. RESULTS: Tissue myeloperoxidase activity was increased, but superoxide dismutase and catalase activities were decreased in bacterial cystitis, while hyaluronic acid treatment reversed these changes. In the hyaluronic acid-treated group, healing of the uroepithelium was observed, while decreased inflammatory cell infiltration was obvious in gentamycin-treated group. E. coli-induced cystitis in all rats resulted in increased contraction responses to carbachol compared with controls (P < 0.01). Treatment with hyaluronic acid, but not gentamycin, significantly (P < 0.05) depressed hypercontractility at maximum carbachol concentrations. In all rats with cystitis, papaverine-induced relaxation was increased, whereas isoproterenol-induced relaxation curves were not different between the studied groups. CONCLUSION: Gentamycin treatment, despite its ameliorative effect on inflammation, had no impact on the contractile dysfunction of the injured bladder. Intravesical hyaluronic acid, in addition to its supportive role in the healing of the epithelium, seems to lower the increased threshold for contraction and to reduce oxidative stress. These findings support a potential role for hyaluronic acid in the treatment of bacterial cystitis.
File Format	HTM / HTML
ISSN	09198172
e-ISSN	14422042
Journal	International Journal of Urology
Issue Number	6
Volume Number	22
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2015-06-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Hyaluronic Acid Microbiology Rats, Wistar Catalase Escherichia Coli Peroxidase Cystitis Escherichia Coli Infections Discipline Urology Adjuvants, Immunologic Complications Drug Therapy Administration & Dosage Pharmacology Muscle Relaxation Metabolism Drug Effects Anti-bacterial Agents Therapeutic Use Urological Agents Pathology Muscle Contraction Animals Administration, Intravesical Enzymology Urinary Bladder Superoxide Dismutase
Content Type	Text
Resource Type	Article
Subject	Urology

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