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Prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in active surveillance patients.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Iremashvili, Viacheslav Barney, Shane L. Manoharan, Murugesan Kava, Bruce R. Parekh, Dipen J. Punnen, Sanoj
Description	Country affiliation: United States Author Affiliation: Iremashvili V ( Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida, USA.); Barney SL ( Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida, USA.); Manoharan M ( Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida, USA.); Kava BR ( Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida, USA.); Parekh DJ ( Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida, USA.); Punnen S ( Department of Urology, Miller School of Medicine, University of Miami, Miami, Florida, USA.)
Abstract	OBJECTIVE: To analyze the association between prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in prostate cancer patients on active surveillance, and to study the effect of prediagnostic prostate-specific antigen values on the predictive performance of prostate-specific antigen velocity and prostate-specific antigen doubling time. METHODS: The study included 137 active surveillance patients with two or more prediagnostic prostate-specific antigen levels measured over a period of at least 3 months. Two sets of analyses were carried out. First, the association between prostate-specific antigen kinetics calculated using only the prediagnostic prostate-specific antigen values and the risk of biopsy progression was studied. Second, using the same cohort of patients, the predictive value of prostate-specific antigen kinetics calculated using only post-diagnostic prostate-specific antigens and compared with that of prostate-specific antigen kinetics based on both pre- and post-diagnostic prostate-specific antigen levels was analyzed. RESULTS: Of 137 patients included in the analysis, 37 (27%) had biopsy progression over a median follow-up period of 3.2 years. Prediagnostic prostate-specific antigen velocity of more than 2 ng/mL/year and 3 ng/mL/year was statistically significantly associated with the risk of future biopsy progression. However, after adjustment for baseline prostate-specific antigen density, these associations were no longer significant. None of the tested prostate-specific antigen kinetics based on combined pre- and post-diagnostic prostate-specific antigen values were statistically significantly associated with the risk of biopsy progression. CONCLUSIONS: Historical prediagnostic prostate-specific antigens seems to be not clinically useful in patients diagnosed with low-risk prostate cancer on active surveillance.
File Format	HTM / HTML
ISSN	09198172
e-ISSN	14422042
Journal	International Journal of Urology
Issue Number	4
Volume Number	23
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2016-04-01
Publisher Place	Australia
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Discipline Urology
Content Type	Text
Resource Type	Article
Subject	Urology

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Comment to Prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in active surveillance patients. : Editorial

Role of Prostate Specific Antigen and Immediate Confirmatory Biopsy in Predicting Progression During Active Surveillance for Low Risk Prostate Cancer

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Is there any association between prostate-specific antigen screening frequency and uptake of active surveillance in men with low or very low risk prostate cancer?

Prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in active surveillance patients.

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Comment to Prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in active surveillance patients. : Editorial

Role of Prostate Specific Antigen and Immediate Confirmatory Biopsy in Predicting Progression During Active Surveillance for Low Risk Prostate Cancer

The relationship between prostate specific antigen change and biopsy progression in patients on active surveillance for prostate cancer.

Active surveillance for prostate cancer: a review.

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Prediagnostic prostate-specific antigen kinetics and the risk of biopsy progression in active surveillance patients.