NDLI: Genes differentially expressed by Aspergillus carbonarius strains under ochratoxin A producing conditions.

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Genes differentially expressed by Aspergillus carbonarius strains under ochratoxin A producing conditions.

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Genes differentially expressed by Aspergillus carbonarius strains under ochratoxin A producing conditions.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Crespo-Sempere, A. González-Candelas, L. Martínez-Culebras, P. V.
Description	Country affiliation: Spain Author Affiliation: Crespo-Sempere A ( Departamento de Medicina Preventiva y Salud Pública, Ciencias de la Alimentación, Bromatología, Toxicología y Medicina Legal, Universitat de València, Valencia, Spain.)
Abstract	Aspergillus carbonarius is an important ochratoxin A (OTA)-producing fungus that is responsible for toxin contamination of grapes and wine, coffee and cocoa. A suppression subtractive hybridization (SSH) approach was performed with two strains of A. carbonarius, antagonistic in their OTA-production ability, to identify genes whose expression is linked with the ability to produce OTA. BlastX analysis identified 109 differentially-expressed sequences putatively involved in the production of OTA, with significant similarities (E(value)<10(-5)) to sequences deposited in the NCBI non-redundant protein database. Of the 109 ESTs, 26% were involved in regulation processes, 15% corresponded to hypothetical proteins, 12% were involved in stress response and detoxification, 9% corresponded to transport and secretion processes, 7% corresponded to amino acid metabolism, 7% were involved in hydrolysis of energy reserves and 5% involved in secondary metabolism. Other unisequences showed homology to genes involved in protein synthesis and general metabolism. According to their sequence similarities to genes in the NCBI database, the possible functional roles they might play in the production and regulation of OTA are discussed. Worth noting is the high percentage of genes involved in regulation, including specific and global regulators. It is also important to note the high percentage of genes involved in the response to stress and detoxification.
File Format	HTM / HTML
ISSN	01681605
Issue Number	1-2
Volume Number	142
e-ISSN	18793460
Journal	International Journal of Food Microbiology
Language	English
Publisher	Elsevier
Publisher Date	2010-08-15
Publisher Place	Netherlands
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Gene Expression Regulation, Fungal Research Support, Non-u.s. Gov't Discipline Microbiology Molecular Sequence Data Fungal Proteins Biosynthesis Metabolism Journal Article Aspergillus Mycotoxins Genetics Ochratoxins Discipline Nutritional Sciences
Content Type	Text
Resource Type	Article
Subject	Medicine Microbiology Safety, Risk, Reliability and Quality Food Science

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Proteome analysis of the fungus Aspergillus carbonarius under ochratoxin A producing conditions.

VeA and LaeA transcriptional factors regulate ochratoxin A biosynthesis in Aspergillus carbonarius.

The loss of the inducible Aspergillus carbonarius MFS transporter MfsA leads to ochratoxin A overproduction.

Clustered array of ochratoxin A biosynthetic genes in Aspergillus steynii and their expression patterns in permissive conditions.

Identification and characterization of the polyketide synthase involved in ochratoxin A biosynthesis in Aspergillus carbonarius.

Effect of phenylpyrrole-resistance on fitness parameters and ochratoxin production in Aspergillus carbonarius.

Grape variety related trans-resveratrol induction affects Aspergillus carbonarius growth and ochratoxin A biosynthesis.

Characterisation of a pks gene which is expressed during ochratoxin A production by Aspergillus carbonarius.

Identification of Genes Differentially Expressed Between Ochratoxin-Producing and Non-Producing Strains of Aspergillus westerdijkiae.

Genes differentially expressed by Aspergillus carbonarius strains under ochratoxin A producing conditions.

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Proteome analysis of the fungus Aspergillus carbonarius under ochratoxin A producing conditions.

VeA and LaeA transcriptional factors regulate ochratoxin A biosynthesis in Aspergillus carbonarius.

The loss of the inducible Aspergillus carbonarius MFS transporter MfsA leads to ochratoxin A overproduction.

Clustered array of ochratoxin A biosynthetic genes in Aspergillus steynii and their expression patterns in permissive conditions.

Identification and characterization of the polyketide synthase involved in ochratoxin A biosynthesis in Aspergillus carbonarius.

Effect of phenylpyrrole-resistance on fitness parameters and ochratoxin production in Aspergillus carbonarius.

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Characterisation of a pks gene which is expressed during ochratoxin A production by Aspergillus carbonarius.

Identification of Genes Differentially Expressed Between Ochratoxin-Producing and Non-Producing Strains of Aspergillus westerdijkiae.

Genes differentially expressed by Aspergillus carbonarius strains under ochratoxin A producing conditions.