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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Meinking, Terri L. Mertz-Rivera, Kamara Villar, Maria Elena Bell, Margie |
| Description | Country affiliation: United States Author Affiliation: Meinking TL ( Global Health Association of Miami, Inc., Miami, FL, USA. terri@ghamiami.com) |
| Abstract | BACKGROUND: Ivermectin is a broad-spectrum parasiticide in widespread systemic use, including as an off-label treatment for head lice infestation. The potential of the topical use of ivermectin as a treatment for head lice infestation was suggested by an in vitro report of a novel lotion formulation. OBJECTIVES: This study investigated the relative effectiveness of three ivermectin lotion concentrations (0.15, 0.25, and 0.5%) compared with vehicle placebo in eliminating head lice infestation. METHODS: In this randomized, blinded study, 78 head lice-infested subjects, aged 2-62 years, received a single, 10-minute application of product on day 1. Evaluations were completed at two and six hours post-application, and on days 2, 8 (±1), and 15 (+2). Safety was assessed according to the evaluations of trained observers and adverse event (AE) reports. Efficacy was assessed according to scalp and hair examinations. RESULTS: Compared with placebo, all ivermectin concentrations resulted in the statistically significant (P ≤ 0.003) eradication of head lice through to day 15, with the highest level of eradication (73.7%) in subjects who received the 0.5% concentration. The severity of pruritus decreased from baseline in all treatment groups, including the placebo group, from six hours post-treatment to day 15, with the greatest reduction in the 0.5% concentration group. No ocular irritation was observed. All three ivermectin treatment strengths and vehicle were well tolerated. CONCLUSIONS: A single application of a 0.5% concentration of this ivermectin lotion formulation shows promise as a safe and effective treatment for head lice infestation and the associated signs of pruritus. |
| File Format | HTM / HTML |
| ISSN | 00119059 |
| Issue Number | 1 |
| Volume Number | 52 |
| e-ISSN | 13654632 |
| Journal | International Journal of Dermatology |
| Language | English |
| Publisher | Wiley-Blackwell |
| Publisher Date | 2013-01-01 |
| Publisher Place | Great Britain (UK) |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Pediculus Scalp Dermatoses Lice Infestations Humans Middle Aged Child, Preschool Insecticides Male Pruritus Journal Article Young Adult Dose-response Relationship, Drug Adult Female Child Adverse Effects Drug Therapy Treatment Outcome Administration & Dosage Randomized Controlled Trial Discipline Dermatology Chemically Induced Pathogenicity Animals Scalp Adolescent Administration, Topical Ivermectin |
| Content Type | Text |
| Resource Type | Article |
| Subject | Dermatology |
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