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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Dulaurent, S. Gaulier, J. M. Imbert, L. Morla, A. Lachâtre, G. |
| Description | Author Affiliation: Dulaurent S ( CHU Dupuytren, Department of Pharmacology and Toxicology, Unit of Biological and Forensic Toxicology, 87042 Limoges, France. Electronic address: sylvain.dulaurent@unilim.fr.); Gaulier JM ( CHU Dupuytren, Department of Pharmacology and Toxicology, Unit of Biological and Forensic Toxicology, 87042 Limoges, France.); Imbert L ( CHU Dupuytren, Department of Pharmacology and Toxicology, Unit of Biological and Forensic Toxicology, 87042 Limoges, France); Morla A ( AB Sciex France, 91940 Les Ulis, France.); Lachâtre G ( CHU Dupuytren, Department of Pharmacology and Toxicology, Unit of Biological and Forensic Toxicology, 87042 Limoges, France) |
| Abstract | For several years, hair analyses have become a powerful tool to investigate past exposure towards xenobiotics. In the case of illicit drugs and more precisely of cannabis exposure, four compounds are usually investigated: Δ(9)-tetrahydrocannabinol (THC), the main active compound of cannabis, one of its metabolites [11-nor-Δ(9)-tetrahydrocannabinol-9-carboxylic acid (THC-COOH)] and two cannabinoids (cannabinol and cannabidiol). Up until now, the hair determination of the carboxylic metabolite of THC, which has been described as the only marker allowing distinguishing consumption and passive exposure, has been performed using a gas chromatography-tandem mass spectrometry method. The aim of this study was to develop a liquid chromatography-tandem mass spectrometry (LC-MS/MS) method for the simultaneous quantitative determination of the four markers. The sample preparation was based on an alkaline hydrolysis of hair samples followed by a liquid-liquid extraction of compounds in acidic conditions using a hexane/ethyl acetate mixture. The method was validated and the results were satisfactory: intra- and inter-assay accuracies below 9% and relative standard deviation below 15% for the four compounds. Moreover, the limit of quantification for THC-COOH, the most challenging compound, was validated at 0.2 pg/mg. This concentration is in accordance with the recommendations made by a scientific society which specializes in hair testing. It makes it possible to distinguish the kind of exposure to cannabis. |
| File Format | HTM / HTML |
| ISSN | 03790738 |
| Volume Number | 236 |
| e-ISSN | 18726283 |
| Journal | Forensic Science International |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2014-03-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Hair Discipline Forensic Science Humans Cannabidiol Forensic Toxicology Hallucinogens Journal Article Tandem Mass Spectrometry Chemistry Analysis Dronabinol Chromatography, Liquid Validation Studies Analogs & Derivatives |
| Content Type | Text |
| Resource Type | Article |
| Subject | Law Pathology and Forensic Medicine |
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