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| Content Provider | World Health Organization (WHO)-Global Index Medicus |
|---|---|
| Author | Andrello, L. Visonà, S. D. Osculati, A. |
| Description | Country affiliation: Italy Author Affiliation: Andrello L ( Department of Biotechnologies and Life Sciences, Section of Legal Medicine, Insubria University, via Guicciardini 9bis, 21100 Varese, Italy.); Visonà SD ( Department of Biotechnologies and Life Sciences, Section of Legal Medicine, Insubria University, via Guicciardini 9bis, 21100 Varese, Italy. Electronic address: sd.visona@studenti.uninsubria.it.); Osculati A ( Department of Biotechnologies and Life Sciences, Section of Legal Medicine, Insubria University, via Guicciardini 9bis, 21100 Varese, Italy.) |
| Abstract | Paragangliomas are cromaffin tumors arising from the neural crest cells of parasympathetic or sympathetic ganglia. They are known to be rare causes of sudden death. Here we present the autopsy findings, as well as microscopical and immunohistochemistry study, of a 48-years-old woman who died suddenly after a percutaneous alcohol injection of a peri-renal cyst previously diagnosed as a common complex cyst. She manifested a multiorgan failure, with acute heart failure, systemic and pulmonary vasoconstriction with hypoxia, metabolic acidosis (pH 6.974). It was therefore enacted resuscitation that was ineffective. The autopsy pointed out, close to the upper right renal pole, a cyst characterized by very friable walls and septa, with a thickness of approximately 0.5cm and containing about 75cm(3) of hemoserous fluid. Microscopically, through immunohistochemical examinations, the cyst showed the presence of chromaffin cells, containing enzymes involved in the synthesis of catecholamines, in particular noradrenalin. So, the cause of the death was ascertained in an multi-organ failure caused by a massive release of catecholamines (noradrenaline) from the cyst, identified post-mortem (on the basis of histologic and immunohistochemical examinations) in a noradrenalin-secreting paraganglioma, that remained silent until the cyst ablation. |
| File Format | HTM / HTML |
| ISSN | 03790738 |
| Volume Number | 253 |
| e-ISSN | 18726283 |
| Journal | Forensic Science International |
| Language | English |
| Publisher | Elsevier |
| Publisher Date | 2015-08-01 |
| Publisher Place | Ireland |
| Access Restriction | One Nation One Subscription (ONOS) |
| Subject Keyword | Discipline Forensic Science Kidney Diseases Ethanol Humans Middle Aged Ultrasonography, Interventional Paraganglioma Administration & Dosage Metabolism Death, Sudden Journal Article Case Reports Multiple Organ Failure Pathology Injections Cysts Etiology Diagnostic Errors Female Norepinephrine Adrenal Gland Neoplasms Diagnosis |
| Content Type | Text |
| Resource Type | Case study Article |
| Subject | Law Pathology and Forensic Medicine |
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