NDLI: The effects of multidisciplinary rehabilitation in patients with early-to-middle-stage Huntington's disease: a pilot study.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Thompson, J. A. Cruickshank, T. M. Penailillo, L. E. Lee, J. W. Newton, R. U. Barker, R. A. Ziman, M. R.
Description	Country affiliation: Australia Author Affiliation: Thompson JA ( School of Medical Sciences, Edith Cowan University, Perth, Australia. jennifer.thompson@ecu.edu.au)
Abstract	BACKGROUND AND PURPOSE: Despite advances in the understanding of Huntington's disease (HD), treatment remains symptomatic. Multidisciplinary rehabilitation, however, appears to impact disease progression. Here we show the feasibility, safety and efficacy of a 9-month multidisciplinary rehabilitation programme in a small cohort of patients with early-to-middle-stage HD. METHODS: Twenty patients with HD were assigned to two groups, equally matched for cognitive and motor scores. One group received the intervention, whilst the other served as control. The Unified-Huntington's-Disease-Rating-Scale-Total-Motor-Score was the primary outcome measure. Neurocognitive/psychological tests, body composition, postural stability, strength and quality of life assessments were secondary outcome measures. RESULTS: The intervention reduced motor and postural stability deterioration, with minor improvements in depression, cognition and quality of life. Significant gains were observed for fat-free mass and strength. CONCLUSION: This pilot study suggests that a prolonged multidisciplinary rehabilitation programme in early-to-middle-stage HD is feasible, well-tolerated and associated with therapeutic benefit. Further explorative, larger studies are warranted.
File Format	HTM / HTML
ISSN	13515101
Issue Number	9
Volume Number	20
e-ISSN	14681331
Journal	European Journal of Neurology
Language	English
Publisher	Wiley-Blackwell
Publisher Date	2013-09-01
Publisher Place	Great Britain (UK)
Access Restriction	Subscribed
Subject Keyword	Huntington Disease Occupational Therapy Research Support, Non-u.s. Gov't Humans Middle Aged Male Treatment Outcome Randomized Controlled Trial Exercise Therapy Journal Article Pilot Projects Discipline Neurology Female Rehabilitation Methods
Content Type	Text
Resource Type	Article
Subject	Neurology Neurology (clinical)

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