NDLI: Using fluorescent aromatic compounds in bile from juvenile salmonids to predict exposure to polycyclic aromatic hydrocarbons.

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Year: 2008 Volume: 27 Issue: 2

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Year: 2006 Volume: 25

Year: 2004 Volume: 23

Using fluorescent aromatic compounds in bile from juvenile salmonids to predict exposure to polycyclic aromatic hydrocarbons.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Meador, James P. Buzitis, Jon Bravo, Claudia F.
Description	Country affiliation: United States Author Affiliation: Meador JP ( Ecotoxicology and Environmental Fish Health Program, Environmental Conservation Division, National Marine Fisheries Service, National Oceanic and Atmospheric Administration, Seattle, Washington 98112, USA. james.meador@noaa.gov)
Abstract	We provide data from four different studies in which fish were fed polycyclic aromatic hydrocarbons (PAHs) that were used to develop a predictive relationship between dose (mug/g fish/d) and metabolites of PAHs in bile. Juvenile salmonids were fed various doses of total PAH that were applied as a mixture to fish pellets. The number of PAHs in each mixture ranged from 10 to 21 different low- and high-molecular-weight compounds, and their relative proportions and abundance were based on stomach concentrations observed for field-collected fish. Although we examined both the phenanthrene (PHN) and benzo[a]pyrene signals for the fluorescent aromatic compounds (FACs) in bile, the PHN signal exhibited the highest correlation and was considered to be the better choice for predicting exposure. A large database of PHN FAC values for field-collected fish was examined and used to predict dose by the method of inverse prediction. The goal of the present study was to develop a predictive relationship that would allow estimation of an exposure dose for an observed value of PHN FACs from juvenile salmonids sampled in the field. This dose would then be used to estimate adverse effects based on toxicity results from laboratory studies. Additional analyses were performed to determine ventilation doses from water concentrations of total PAH and then relate those to PHN FAC values.
File Format	HTM / HTML
ISSN	07307268
Issue Number	4
Volume Number	27
e-ISSN	15528618
Journal	Environmental Toxicology and Chemistry
Language	English
Publisher	Wiley
Publisher Date	2008-04-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Water Pollutants, Chemical Environmental Monitoring Toxicity Salmon Discipline Environmental Health Fluorescence Discipline Toxicology Polycyclic Hydrocarbons, Aromatic Benzo(a)pyrene Metabolism Journal Article Phenanthrenes Chemistry Animals Analysis Discipline Chemistry Methods Bile
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

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