NDLI: Test of significant toxicity: a statistical application for assessing whether an effluent or site water is truly toxic.

Content Provider	World Health Organization (WHO)-Global Index Medicus
Author	Denton, Debra L. Diamond, Jerry Zheng, Lei
Spatial Coverage	United States
Description	Country affiliation: United States Author Affiliation: Denton DL ( U.S. Environmental Protection Agency, Sacramento, California, USA. denton.debra@epa.gov)
Abstract	The U.S. Environmental Protection Agency (U.S. EPA) and state agencies implement the Clean Water Act, in part, by evaluating the toxicity of effluent and surface water samples. A common goal for both regulatory authorities and permittees is confidence in an individual test result (e.g., no-observed-effect concentration [NOEC], pass/fail, 25% effective concentration [EC25]), which is used to make regulatory decisions, such as reasonable potential determinations, permit compliance, and watershed assessments. This paper discusses an additional statistical approach (test of significant toxicity [TST]), based on bioequivalence hypothesis testing, or, more appropriately, test of noninferiority, which examines whether there is a nontoxic effect at a single concentration of concern compared with a control. Unlike the traditional hypothesis testing approach in whole effluent toxicity (WET) testing, TST is designed to incorporate explicitly both and ß error rates at levels of toxicity that are unacceptable and acceptable, given routine laboratory test performance for a given test method. Regulatory management decisions are used to identify unacceptable toxicity levels for acute and chronic tests, and the null hypothesis is constructed such that test power is associated with the ability to declare correctly a truly nontoxic sample as acceptable. This approach provides a positive incentive to generate high-quality WET data to make informed decisions regarding regulatory decisions. This paper illustrates how and ß error rates were established for specific test method designs and tests the TST approach using both simulation analyses and actual WET data. In general, those WET test endpoints having higher routine (e.g., 50th percentile) within-test control variation, on average, have higher method-specific values (type I error rate), to maintain a desired type II error rate. This paper delineates the technical underpinnings of this approach and demonstrates the benefits to both regulatory authorities and permitted entities.
File Format	HTM / HTML
ISSN	07307268
Issue Number	5
Volume Number	30
e-ISSN	15528618
Journal	Environmental Toxicology and Chemistry
Language	English
Publisher	Wiley
Publisher Date	2011-05-01
Publisher Place	United States
Access Restriction	One Nation One Subscription (ONOS)
Subject Keyword	Water Pollutants, Chemical Water Pollution, Chemical Data Interpretation, Statistical Toxicity United States Discipline Environmental Health Discipline Toxicology Standards Journal Article Analysis Discipline Chemistry Statistics & Numerical Data United States Environmental Protection Agency Evaluation Studies Toxicity Tests Methods
Content Type	Text
Resource Type	Article
Subject	Environmental Chemistry Health, Toxicology and Mutagenesis

Sl.	Authority	Responsibilities	Communication Details
1	Ministry of Education (GoI), Department of Higher Education	Sanctioning Authority	https://www.education.gov.in/ict-initiatives
2	Indian Institute of Technology Kharagpur	Host Institute of the Project: The host institute of the project is responsible for providing infrastructure support and hosting the project	https://www.iitkgp.ac.in
3	National Digital Library of India Office, Indian Institute of Technology Kharagpur	The administrative and infrastructural headquarters of the project	Dr. B. Sutradhar bsutra@ndl.gov.in
4	Project PI / Joint PI	Principal Investigator and Joint Principal Investigators of the project	Dr. B. Sutradhar bsutra@ndl.gov.in Prof. Saswat Chakrabarti will be added soon
5	Website/Portal (Helpdesk)	Queries regarding NDLI and its services	support@ndl.gov.in
6	Contents and Copyright Issues	Queries related to content curation and copyright issues	content@ndl.gov.in
7	National Digital Library of India Club (NDLI Club)	Queries related to NDLI Club formation, support, user awareness program, seminar/symposium, collaboration, social media, promotion, and outreach	clubsupport@ndl.gov.in
8	Digital Preservation Centre (DPC)	Assistance with digitizing and archiving copyright-free printed books	dpc@ndl.gov.in
9	IDR Setup or Support	Queries related to establishment and support of Institutional Digital Repository (IDR) and IDR workshops	idr@ndl.gov.in

Evaluation of whole effluent toxicity data characteristics and use of Welch's T-test in the test of significant toxicity analysis.

It is time for changes in the analysis of whole effluent toxicity data.

Evaluation of the test of significant toxicity for determining the toxicity of effluents and ambient water samples.

Chronic toxicity of chloride to freshwater species: effects of hardness and implications for water quality guidelines.

Comparative acute and chronic sensitivity of fish and amphibians: a critical review of data.

Application of chemical toxicity distributions to ecotoxicology data requirements under REACH.

Evaluation of influence of sediment on the sensitivity of a unionid mussel (Lampsilis siliquoidea) to ammonia in 28-day water exposures.

Application of U.S. EPA guidelines in a bioavailability-based assessment of ambient water quality criteria for zinc in freshwater

How accurate are physical property estimation programs for organosilicon compounds?

Test of significant toxicity: a statistical application for assessing whether an effluent or site water is truly toxic.

Similar Documents

Evaluation of whole effluent toxicity data characteristics and use of Welch's T-test in the test of significant toxicity analysis.

It is time for changes in the analysis of whole effluent toxicity data.

Evaluation of the test of significant toxicity for determining the toxicity of effluents and ambient water samples.

Chronic toxicity of chloride to freshwater species: effects of hardness and implications for water quality guidelines.

Comparative acute and chronic sensitivity of fish and amphibians: a critical review of data.

Application of chemical toxicity distributions to ecotoxicology data requirements under REACH.

Evaluation of influence of sediment on the sensitivity of a unionid mussel (Lampsilis siliquoidea) to ammonia in 28-day water exposures.

Application of U.S. EPA guidelines in a bioavailability-based assessment of ambient water quality criteria for zinc in freshwater

How accurate are physical property estimation programs for organosilicon compounds?

Test of significant toxicity: a statistical application for assessing whether an effluent or site water is truly toxic.